Schmith V D, Foss J F
Department of Clinical Pharmacokinetics/Modeling and Simulation, GlaxoSmithKline, Research Triangle Park, North Carolina, USA.
Clin Pharmacol Ther. 2008 Jun;83(6):809-11. doi: 10.1038/clpt.2008.62.
Inflammation is an interesting phenomenon that crosses many disciplines as part of the host response to disease, whether it is the acute response to an infectious, traumatic, or surgical event or the more chronic responses to systemic disease such as malignancy, rheumatoid arthritis, asthma, inflammatory bowel disease, or diabetes. The impact of inflammatory states on the variability in drug response should be an integral part of research conducted across disciplines within clinical pharmacology.
炎症是一种有趣的现象，作为机体对疾病的反应的一部分，它跨越了许多学科领域，无论是对感染、创伤或手术事件的急性反应，还是对诸如恶性肿瘤、类风湿性关节炎、哮喘、炎症性肠病或糖尿病等全身性疾病的更慢性反应。炎症状态对药物反应变异性的影响应成为临床药理学各学科研究不可或缺的一部分。
