Maoz C, Shitrit D, Samra Z, Peled N, Kaufman L, Kramer M R, Bishara J
Recanati Center for Medicine and Research, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Israel.
Eur J Clin Microbiol Infect Dis. 2008 Oct;27(10):945-50. doi: 10.1007/s10096-008-0522-6. Epub 2008 May 17.
To identify the clinical and radiological features distinguishing Mycobacterium simiae respiratory infection from pulmonary tuberculosis, the demographics, underlying conditions, and clinical and radiological findings of 121 consecutive patients with pulmonary tuberculosis and 102 with M. simiae respiratory infection were compared retrospectively. In the M. simiae group, the patients were older (mean age 69 +/- 16 years vs. 47 +/- 21 years, p = 0.0001), with a female predominance (62% vs. 45%, p = 0.008). Only 4% were of Ethiopian origin compared to 25% of the tuberculosis group (p = 0.0001). M. simiae infection was associated with significantly higher rates of smoking history, underlying chronic obstructive pulmonary disease, zero human immunodeficiency virus (HIV) infection compared to 10% in the tuberculosis group (p = 0.001), blunted symptoms, and noncavitary infiltrates in the lower/middle lobes on chest X-ray. HIV-negative patients with M. simiae respiratory infection are distinguishable from patients with pulmonary tuberculosis by several demographic, clinical, and radiological features. These findings have important diagnostic and therapeutic implications.
为了确定区分猿分枝杆菌呼吸道感染与肺结核的临床和放射学特征，我们对121例连续性肺结核患者和102例猿分枝杆菌呼吸道感染患者的人口统计学资料、基础疾病以及临床和放射学表现进行了回顾性比较。在猿分枝杆菌组中，患者年龄较大（平均年龄69±16岁 vs. 47±21岁，p = 0.0001），女性占多数（62% vs. 45%，p = 0.008）。与肺结核组25%的患者相比，只有4%的患者来自埃塞俄比亚（p = 0.0001）。猿分枝杆菌感染与吸烟史、基础慢性阻塞性肺疾病的发生率显著较高相关，与肺结核组10%的患者相比，人类免疫缺陷病毒（HIV）感染率为零（p = 0.001），症状不典型，胸部X线显示下/中叶非空洞性浸润。猿分枝杆菌呼吸道感染的HIV阴性患者在人口统计学、临床和放射学特征方面与肺结核患者有所不同。这些发现具有重要的诊断和治疗意义。
