Bell R C, Higuchi J H, Donovan W N, Krasnow I, Johanson W G
Am Rev Respir Dis. 1983 Jan;127(1):35-8. doi: 10.1164/arrd.1983.127.1.35.
The charts of twenty-four patients from whom Mycobacterium simiae was isolated from the sputum were reviewed and the patients seen in follow-up examination when possible. They were divided into 3 groups: 2 patients were felt to have had definite infection with M. simiae, 3 were felt to have had probable infection, and 19 showed no evidence of infection during follow-up for as long as 6 yr. All patients in the study had underlying pulmonary abnormalities. The results of PPD skin tests were negative in patients without evidence of tuberculosis. The patients without evidence of M. simiae infection were found to have had negative initial Acid Fast Bacillus smears, fewer sputum cultures positive for M. simiae, and lighter yields from cultures of M. simiae compared with those in the patients with M. simiae infection. We conclude that M. simiae is a nontuberculous mycobacterium capable of causing progressive granulomatous lung infection, but that it may also be identified as a causal isolate from the sputum of susceptible persons. Antituberculosis chemotherapy should not be employed in this latter group.
对24例痰中分离出猿猴分枝杆菌的患者病历进行了回顾，并尽可能对患者进行随访检查。他们被分为3组：2例被认为确诊感染猿猴分枝杆菌，3例被认为可能感染，19例在长达6年的随访期间未显示感染证据。该研究中的所有患者均有潜在肺部异常。无结核病证据的患者结核菌素皮肤试验结果为阴性。与感染猿猴分枝杆菌的患者相比，未感染猿猴分枝杆菌的患者初始抗酸杆菌涂片阴性，痰培养中猿猴分枝杆菌阳性较少，且猿猴分枝杆菌培养产量较低。我们得出结论，猿猴分枝杆菌是一种能够引起进行性肉芽肿性肺部感染的非结核分枝杆菌，但它也可能被鉴定为易感人群痰液中的致病分离株。后一组患者不应采用抗结核化疗。
