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[年龄相关性黄斑变性患者的眼内疱疹病毒感染与抗病毒免疫]

[Intraocular infection with herpesviruses and antiviral immunity in patients with age-related macular degeneration].

作者信息

Mukhamed'ianova A Sh, Aznabaev R A, Aznabaeva L F

出版信息

Vestn Oftalmol. 2008 Mar-Apr;124(2):39-42.

PMID:18488471
Abstract

Polymerase chain reaction revealed Herpesviridae (Herpes simplex, Cytomegalovirus) in the lens substance in 46 patients operated on for age-related cataract. Thirty-two patients of them had age-related macular degeneration. Herpes simplex was found in 6 (18.8%) of the patients with age-related macular degeneration. At the same time there were signs of lacrimal fluid antiviral immunity imbalance with decreased IFN-gamma and TNF-alpha and increased IFN-alpha. The authors consider it advisable to perform antivirus treatment in patients with the above abnormality, preventing the active forms of herpetic infection.

摘要

聚合酶链反应显示,在46例因年龄相关性白内障接受手术的患者晶状体物质中发现了疱疹病毒科(单纯疱疹病毒、巨细胞病毒)。其中32例患者患有年龄相关性黄斑变性。在患有年龄相关性黄斑变性的患者中,6例(18.8%)发现了单纯疱疹病毒。同时,存在泪液抗病毒免疫失衡的迹象,γ干扰素和肿瘤坏死因子α减少,α干扰素增加。作者认为,对有上述异常的患者进行抗病毒治疗是可取的,以预防疱疹感染的活跃形式。

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HSV-1 Infection in Retinal Pigment Epithelial Cells: A Possible Contribution to Age-Related Macular Degeneration.单纯疱疹病毒1型在视网膜色素上皮细胞中的感染:对年龄相关性黄斑变性的可能作用。
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Undaria pinnatifida fucoidan extract inhibits activation of the NF-κB signaling pathway by herpes simplex virus type 1 and prevents amyloid-β peptide synthesis in retinal pigment epithelium cells.裙带菜岩藻聚糖提取物可抑制单纯疱疹病毒1型对NF-κB信号通路的激活,并防止视网膜色素上皮细胞中淀粉样β肽的合成。
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