Biological Science Laboratories, Kao Corporation, Tochigi 321-3497, Japan.
Int J Cosmet Sci. 2007 Dec;29(6):423-36. doi: 10.1111/j.1468-2494.2007.00399.x.
The global and systematic demonstration for the practical usage of a direct three-dimensional in vivo measurement system (PRIMOS) to evaluate wrinkles was investigated. Ten repetitive measurements of the corner of the eye of a subject showed that the coefficient of variation (CV)% value was 7.0% in a typical line-length roughness parameter R(a) (the arithmetic mean of roughness), and that the CV% value in a typical surface area roughness parameter S(a) was 2.4%. The relationships between the roughness values obtained from the corners of the eye and the age or wrinkle scores of Japanese women aged 10-70 years was examined. The values of several roughness parameters within the evaluation line length or surface area increased with age and showed a good correlation coefficient (r > 0.743). Similar relationships between the wrinkle scores and the values of roughness parameters were observed (r > 0.699). The roughness values were widely distributed even in the same wrinkle score because the measurement areas were limited and the values of skin roughness, including the microreliefs and/or small warts, were included in the calculation. However, changes in roughness values are considerable following treatment with potent active ingredients such as retinoic acid, so that this in vivo evaluation method is sufficient to objectively evaluate wrinkles. We conclude that the direct three-dimensional analysis of wrinkles in vivo should become a popular method to objectively evaluate wrinkles in clinical tests of wrinkle-smoothing ingredients or following cosmetic surgery to provide evidence of quantitative results.
本研究旨在全球范围内系统地展示一种直接的三维体内测量系统（PRIMOS）在评估皱纹方面的实际应用。对受试者眼角进行了十次重复测量，结果显示典型线粗糙度参数 R(a)（粗糙度的算术平均值）的变异系数（CV）%值为 7.0%，典型表面粗糙度参数 S(a)的 CV%值为 2.4%。还研究了眼角粗糙度值与 10-70 岁日本女性的年龄或皱纹评分之间的关系。评估线长度或表面积内的几个粗糙度参数值随年龄增加而增加，相关系数（r > 0.743）较好。粗糙度参数值与皱纹评分之间也存在类似的关系（r > 0.699）。由于测量区域有限，包括微凸体和/或小疣在内的皮肤粗糙度值也包含在计算中，因此即使在相同的皱纹评分中，粗糙度值也分布广泛。然而，在使用维甲酸等有效活性成分进行治疗后，粗糙度值的变化相当大，因此这种体内评估方法足以客观评估皱纹。我们得出结论，直接对皱纹进行三维分析可能成为临床评估皱纹平滑成分或美容手术后客观评估皱纹的一种流行方法，为定量结果提供证据。
