Unilever R&D, Colworth Discover, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, U.K.
Int J Cosmet Sci. 2014 Feb;36(1):22-31. doi: 10.1111/ics.12087. Epub 2013 Sep 18.
The maintenance of youthful skin appearance is strongly desired by a large proportion of the world's population. The aim of the present study was therefore to evaluate the effect on skin wrinkling, of a combination of ingredients reported to influence key factors involved in skin ageing, namely inflammation, collagen synthesis and oxidative/UV stress. A supplemented drink was developed containing soy isoflavones, lycopene, vitamin C and vitamin E and given to post-menopausal women with a capsule containing fish oil.
We have performed a double-blind randomized controlled human clinical study to assess whether this cocktail of dietary ingredients can significantly improve the appearance of facial wrinkles.
We have shown that this unique combination of micronutrients can significantly reduce the depth of facial wrinkles and that this improvement is associated with increased deposition of new collagen fibres in the dermis.
This study demonstrates that consumption of a mixture of soy isoflavones, lycopene, vitamin C, vitamin E and fish oil is able to induce a clinically measureable improvement in the depth of facial wrinkles following long-term use. We have also shown, for the first time with an oral product, that the improvement is associated with increased deposition of new collagen fibres in the dermis.
保持年轻的皮肤外观是世界上很大一部分人强烈渴望的。因此，本研究的目的是评估一种组合成分对皮肤皱纹的影响，这些成分据报道能影响皮肤老化的关键因素，即炎症、胶原蛋白合成以及氧化/UV 应激。开发了一种含有大豆异黄酮、番茄红素、维生素 C 和维生素 E 的补充饮料，并给绝经后妇女服用一种含有鱼油的胶囊。
我们进行了一项双盲随机对照人体临床研究，以评估这种饮食成分的鸡尾酒是否能显著改善面部皱纹的外观。
我们已经表明，这种独特的微量营养素组合可以显著减少面部皱纹的深度，并且这种改善与真皮中新的胶原蛋白纤维的沉积增加有关。
这项研究表明，长期食用大豆异黄酮、番茄红素、维生素 C、维生素 E 和鱼油的混合物能够诱导面部皱纹深度的临床可测量的改善。我们还首次通过口服产品表明，这种改善与真皮中新的胶原蛋白纤维的沉积增加有关。
