Aytac Erman, Seymen Pinar, Dikmen Goksel, Uzun Hafize, Seymen Hakki Oktay
Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Asian J Surg. 2008 Apr;31(2):69-74. doi: 10.1016/S1015-9584(08)60061-5.
To evaluate the effects of iloprost administration before unilateral nephrectomy on postoperative interleukin-6 (IL-6), nitric oxide (NO), and oxidant/antioxidant status.
Malondialdehyde, glutathione, catalase and Cu-Zn superoxide dismutase were measured in the blood and remnant kidney of Adult male Wistar albino rats to assess oxidant and antioxidant status. The rats were divided into three experimental groups: sham group (S) (n = 12); unilateral nephrectomized group (N) (n = 12); an hour before unilateral nephrectomy iloprost (1 ng/mL/kg, intraperitoneal) administered group (IN) (n = 12).
Iloprost administration before unilateral nephrectomy lowered oxidant parameters and IL-6 levels significantly. NO levels were increased in both N and IN groups.
Iloprost pretreatment before unilateral nephrectomy can reduce oxidative stress and IL-6, which increases due to anaesthesia and surgery and causes organ damage during surgery and in the short-term postoperative period.
评估在单侧肾切除术前给予伊洛前列素对术后白细胞介素-6（IL-6）、一氧化氮（NO）以及氧化/抗氧化状态的影响。
测定成年雄性Wistar白化大鼠血液和残余肾脏中的丙二醛、谷胱甘肽、过氧化氢酶和铜锌超氧化物歧化酶，以评估氧化和抗氧化状态。将大鼠分为三个实验组：假手术组（S）（n = 12）；单侧肾切除组（N）（n = 12）；在单侧肾切除术前一小时给予伊洛前列素（1 ng/mL/kg，腹腔注射）的组（IN）（n = 12）。
单侧肾切除术前给予伊洛前列素可显著降低氧化参数和IL-6水平。N组和IN组的NO水平均升高。
单侧肾切除术前进行伊洛前列素预处理可减轻氧化应激和IL-6，IL-6会因麻醉和手术而升高，并在手术期间及术后短期内导致器官损伤。
