Martinez Antonio, Sanchez Manuel
Instituto Gallego de Oftalmología, C/ Ramón Baltar Sn, Santiago de Compostela, La Coruña 15706, Spain.
Graefes Arch Clin Exp Ophthalmol. 2008 Sep;246(9):1341-9. doi: 10.1007/s00417-008-0841-4. Epub 2008 May 20.
To compare the hemodynamic parameters in the retrobulbar vessels in pseudoexfoliative syndrome (PXS), pseudoexfoliative glaucoma (PXG), and age-matched healthy subjects by using color Doppler imaging (CDI).
72 eyes from 72 patients with PXS, 70 eyes from 70 patients with PXG, and 66 eyes from 66 age-matched healthy subjects who met the inclusion/exclusion criteria were included in this prospective cross-sectional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and Pourcelot resistance index (RI) were assessed in the ophthalmic artery (OA), central retinal artery (CRA), and temporal short-posterior ciliary arteries (SPCA). Visual function was assessed using the 24-2 Swedish Interactive Threshold Algorithm (SITA). The main outcomes of the study were PSV, EDV and RI in the OA, SPCA, and CRA.
The EDV in the OA, SPCA and the CRA was decreased significantly (p < 0.001, <0.001, and 0.003 respectively) in the eyes of PXG patients compared with controls and PSX respectively. The RI in the OA, SPCA, and the CRA was significantly higher (p = 0.022, 0.005, and 0.007 respectively) in the eyes of PXG patients compared with healthy controls and PSX patients respectively. The mean difference in mean EDV in the OA between the control group and the PXS was 0.18 cm/s, 95% confidence interval (CI) -0.60 to 0.95, p = 0.661. The mean difference in mean EDV in the SPCA between the control healthy subjects and the pseudoexfoliative subjects was -0.18 cm/s, 95% CI -0.45 to 0.08, p = 0.176. Multivariate regression analysis showed that in the PXG patients the PSV and EDV in the CRA were significantly positively correlated with the mean defect (p = 0.006 and 0.002 respectively). The RI in the CRA was significantly negatively correlated with the mean defect in PXG patients, p = 0.009.
The results of this study showed that the retrobulbar hemodynamics might be disturbed in patients with PXG, especially in the central retinal artery. Our results have found no significant differences in the retrobulbar hemodynamic parameters between pseudoexfoliative syndrome patients and age-matched healthy subjects.
通过彩色多普勒成像（CDI）比较剥脱性综合征（PXS）、剥脱性青光眼（PXG）患者及年龄匹配的健康受试者球后血管的血流动力学参数。
本前瞻性横断面研究纳入了72例符合纳入/排除标准的PXS患者的72只眼、70例PXG患者的70只眼以及66例年龄匹配的健康受试者的66只眼。评估眼动脉（OA）、视网膜中央动脉（CRA）和颞侧睫状后短动脉（SPCA）的收缩期峰值流速（PSV）、舒张末期流速（EDV）和泊肃叶阻力指数（RI）。使用24-2瑞典交互式阈值算法（SITA）评估视功能。本研究的主要结果是OA、SPCA和CRA中的PSV、EDV和RI。
与对照组和PXS组相比，PXG患者眼中OA、SPCA和CRA的EDV显著降低（分别为p < 0.001、<0.001和0.003）。与健康对照组和PXS患者相比，PXG患者眼中OA、SPCA和CRA的RI显著升高（分别为p = 0.022、0.005和0.007）。对照组与PXS组之间OA平均EDV的平均差异为0.18 cm/s，95%置信区间（CI）为-0.60至0.95，p = 0.661。健康对照组与剥脱性综合征受试者之间SPCA平均EDV的平均差异为-0.18 cm/s，95%CI为-0.45至0.08，p = 0.176。多因素回归分析显示，在PXG患者中，CRA的PSV和EDV与平均缺损显著正相关（分别为p = 0.006和0.002）。PXG患者中CRA的RI与平均缺损显著负相关，p = 0.009。
本研究结果表明，PXG患者的球后血流动力学可能受到干扰，尤其是视网膜中央动脉。我们的结果发现，剥脱性综合征患者与年龄匹配的健康受试者之间的球后血流动力学参数无显著差异。
