Wang Guilin, Uludag Hasan
Faculty of Engineering University of Alberta, Department of Chemical & Materials Engineering, #526 CME Building, Edmonton, Alberta, T6G2G6, Canada.
Expert Opin Drug Deliv. 2008 May;5(5):499-515. doi: 10.1517/17425247.5.5.499.
Drug delivery systems with nm dimensions (nanoparticles [NPs]) are attracting increasing attention because they can sequester drugs in systemic circulation, prevent non-specific biodistribution, and target to specific tissues.
We reviewed the recent literature pertinent to NP-based drug delivery, primarily emphasizing NPs fabricated from proteins.
A summary of common NP fabrication techniques is provided along with the range of sizes and functional properties obtained. The NP properties critical for injectable drug delivery are reviewed, as well as the attempts to design 'tissue-specific' NPs.
RESULTS/CONCLUSIONS: It has been possible to design > 100 nm NPs from different biomaterials, and further understanding of in vivo stability and interactions with physiologic systems will lead to improved drug delivery systems.
纳米尺寸的药物递送系统（纳米颗粒 [NPs]）正吸引着越来越多的关注，因为它们可以在体循环中隔离药物，防止非特异性生物分布，并靶向特定组织。
我们回顾了近期与基于纳米颗粒的药物递送相关的文献，主要侧重于由蛋白质制成的纳米颗粒。
提供了常见纳米颗粒制备技术的总结以及所获得的尺寸范围和功能特性。综述了对可注射药物递送至关重要的纳米颗粒特性，以及设计“组织特异性”纳米颗粒的尝试。
结果/结论：已经能够用不同的生物材料设计出大于100纳米的纳米颗粒，对体内稳定性以及与生理系统相互作用的进一步了解将带来改进的药物递送系统。
