Katz Warren A, Barkin Robert L
Penn-Presbyterian Medical Center, University of Pennsylvania School of Medicine, Rothman Institute, Philadelphia, PA 19107, USA.
Am J Ther. 2008 May-Jun;15(3):256-64. doi: 10.1097/MJT.0b013e3181671c5a.
The burden of chronic/persistent pain is substantial for the patient and society as a whole. Although a variety of pharmacologic treatments are available, chronic/persistent pain remains inadequately treated. Many pharmacologic treatment options provide analgesic efficacy for 4 to 6 hours, requiring multiple doses for continuous pain relief. The inconvenience of multiple doses may prevent many patients from achieving adequate pain relief. Other limitations to the current pharmacologic treatment options include gastrointestinal effects, cardiovascular effects, and organ toxicity, as well as fear of abuse or addiction. The purpose of this review is to highlight the burden of chronic/persistent pain in today's society and discuss the limitations of short-acting pharmacologic therapies used in the treatment of chronic/persistent pain.
慢性/持续性疼痛给患者乃至整个社会都带来了沉重负担。尽管有多种药物治疗方法可供选择，但慢性/持续性疼痛的治疗仍不充分。许多药物治疗方案的镇痛效果只能维持4至6小时，需要多次给药才能持续缓解疼痛。多次给药带来的不便可能使许多患者无法获得充分的疼痛缓解。当前药物治疗方案的其他局限性包括胃肠道影响、心血管影响、器官毒性以及对药物滥用或成瘾的担忧。本综述的目的是强调当今社会中慢性/持续性疼痛的负担，并讨论用于治疗慢性/持续性疼痛的短效药物疗法的局限性。
