Pearce Daniel, Bonnet Dominique
Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.
Mech Ageing Dev. 2009 Jan-Feb;130(1-2):54-7. doi: 10.1016/j.mad.2008.04.005. Epub 2008 Apr 22.
As we humans are far too aware, all mammals have a finite lifespan. Apart from basic longevity, age is also a major risk factor for most cancers and diseases. Since adult stem cells are responsible for maintaining tissue homeostasis throughout an organism's lifetime, an attractive theory is that ageing-related phenotypes might be, at least in part, due to an alteration in the number and/or function of tissue stem cells. Here, we have focused on hematopoietic stem cells as they are one of the best-characterized adult stem cell populations, and have been extensively studied for the consequences of ageing in vivo and in vitro.
我们人类非常清楚，所有哺乳动物的寿命都是有限的。除了基本的长寿外，年龄也是大多数癌症和疾病的主要风险因素。由于成体干细胞负责在生物体的整个生命周期中维持组织稳态，一个有吸引力的理论是，与衰老相关的表型可能至少部分是由于组织干细胞数量和/或功能的改变。在这里，我们重点研究了造血干细胞，因为它们是特征最明确的成体干细胞群体之一，并且已经对其在体内和体外衰老的后果进行了广泛研究。
