各种饮用水在体外人血淋巴细胞（HULYs）中的毒性和致突变性评估。
The evaluation of toxicity and mutagenicity of various drinking waters in the human blood lymphocytes (HULYs) in vitro.
作者信息
Ergene Serap, Celik Ayla, Cavaş Tolga, Köleli Nurcan, Aymak Cemil
机构信息
Department of Biology, Faculty of Science and Letters, Mersin University, 33342 Mersin, Turkey.
出版信息
Food Chem Toxicol. 2008 Jul;46(7):2472-5. doi: 10.1016/j.fct.2008.04.003. Epub 2008 Apr 12.
The aim of the study was to evaluate the toxic and mutagenic effects of bottled purified and natural spring waters for drinking. The study presents the genotoxicologic results of drinking water samples packaged in polyethylene terephthalate (PET) bottles. Genotoxic agents have the potential to interact with DNA and may cause DNA damage. Endpoints analyzed included mitotic index (MI), replication index (RI), and sister chromatid exchange (SCE). An analysis of variance test (ANOVA) was performed to evaluate the results. A significant decrease in MI and RI was observed compared with negative control cultures, respectively, (p<0.05, p<0.01). It is found that SCE frequency increases compared with negative control. There is no significant difference between negative control and drinking water samples and among drinking water samples for sister chromatid exchange induction (p>0.05).
本研究的目的是评估瓶装饮用纯净水和天然泉水的毒性和诱变作用。该研究展示了包装在聚对苯二甲酸乙二酯（PET）瓶中的饮用水样本的遗传毒理学结果。遗传毒性剂有可能与DNA相互作用并可能导致DNA损伤。分析的指标包括有丝分裂指数（MI）、复制指数（RI）和姐妹染色单体交换（SCE）。进行方差分析（ANOVA）以评估结果。与阴性对照培养物相比，MI和RI分别显著降低（p<0.05，p<0.01）。发现SCE频率与阴性对照相比有所增加。在阴性对照和饮用水样本之间以及饮用水样本之间，对于姐妹染色单体交换诱导没有显著差异（p>0.05）。
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