DeMet E M, Reist C, Bell K M, Gerner R H, Chicz-DeMet A, Warren S, Wu J
Department of Psychiatry and Human Behavior, University of California, Irvine 92717.
Biol Psychiatry. 1991 Mar 1;29(5):427-40. doi: 10.1016/0006-3223(91)90265-n.
Seasonal cycles of platelet 3H-imipramine binding were compared in 49 endogenous unipolar depressed patients and 20 normal volunteers. A significant sinusoidal component was detected in the Bmax of binding in both patients and controls with similar amplitudes and seasonal peaks. However, the yearly average (mesor) of the patient group was significantly lower (20.0%) than that of the normal controls. The results support earlier claims of a diminished platelet binding in endogenous depression and indicate that this decrease was still evident in the presence of a 48.2% (controls) to 65.8% (patients) seasonal variation. Control Bmax values were normally distributed about a best-fit mean (cosinor fit). In contrast, patient values appeared to be bimodally distributed with one mode that was similar to controls and one mode that was substantially lower. In general, psychiatric symptoms failed to distinguish between patients with high and low platelet binding and no correlation was found between Bmax and severity of illness (HAM-D).
对49名内源性单相抑郁症患者和20名正常志愿者的血小板3H-丙咪嗪结合的季节性周期进行了比较。在患者和对照组的结合Bmax中均检测到显著的正弦成分，其振幅和季节性峰值相似。然而，患者组的年平均值（中值）显著低于正常对照组（20.0%）。结果支持了早期关于内源性抑郁症中血小板结合减少的说法，并表明在存在48.2%（对照组）至65.8%（患者组）的季节性变化的情况下，这种减少仍然明显。对照组的Bmax值围绕最佳拟合均值（余弦分析拟合）呈正态分布。相比之下，患者的值似乎呈双峰分布，一种模式与对照组相似，另一种模式则显著较低。总体而言，精神症状无法区分血小板结合高和低的患者，且未发现Bmax与疾病严重程度（汉密尔顿抑郁量表）之间存在相关性。
