Institut de recherche Pierre Fabre, Immeuble Zodiaque 2, 3 passage de l’Europe, BP 4404, 31405 Toulouse Cedex 4, France.
Int J Cosmet Sci. 2000 Dec;22(6):421-35.
A new method for the in vivo characterization of the physical properties of skin is presented. This comprises an ultrasound device to measure the vertical displacement of the surface of the skin, as well as its thickness and that of the hypodermis under suction. In combination with this, a mathematical model is used to calculate the following skin parameters: Young's modulus, the initial stress and an index of non-elasticity. These parameters were evaluated from the volar forearm and the forehead of 30 male and 30 females, of similar ages (28 +/- 6-years-old). The sensitivity of the testing procedure, allowing the characterization of the mechanical parameters of the skin, easily differentiated these two sites, and in some cases, differences between women and men were demonstrated. The main results showed for both sexes that the thickness (P = 0.0001), Young's modulus (P = 0.0001), and the index of non-elasticity (P = 0.0001) were greater for the forehead than for the ventral forearm, but that the initial stress was lower (P = 0.0001). The results show that the skin is thicker, stiffer and less tense and elastic on the forehead than on the ventral forearm, suggesting structural differences between these two sites (collagen fibre network, elastic fibres, epidermis, stratum corneum, microvascularization, actinic damage, presence of sebaceous glands, etc.). It is hoped that this device will be useful for the evaluation of certain skin disorders (scleroderma, Ehlers-Danlos syndrome, cutis laxa, oedema, etc.) and their therapy, as well as being a useful tool in skin ageing and cosmetic product assessment.
提出了一种用于体内皮肤物理特性表征的新方法。该方法包括一个超声设备，用于测量皮肤表面的垂直位移及其在抽吸下的厚度和皮下组织厚度。结合这一点，使用数学模型来计算以下皮肤参数：杨氏模量、初始应力和非弹性指数。这些参数是从 30 名男性和 30 名女性的掌侧前臂和额部评估的，年龄相似（28 +/- 6 岁）。测试程序的灵敏度允许对皮肤机械参数进行特征化，很容易区分这两个部位，并且在某些情况下，证明了男女之间的差异。主要结果表明，对于两性，额部的厚度（P = 0.0001）、杨氏模量（P = 0.0001）和非弹性指数（P = 0.0001）都大于掌侧前臂，但初始应力较低（P = 0.0001）。结果表明，与掌侧前臂相比，额部皮肤较厚、较硬、张力和弹性较低，这表明这两个部位存在结构差异（胶原纤维网络、弹性纤维、表皮、角质层、微血管化、光损伤、皮脂腺存在等）。希望该设备将有助于评估某些皮肤疾病（硬皮病、埃勒斯-当洛斯综合征、皮肤松弛症、水肿等）及其治疗方法，以及在皮肤老化和化妆品评估中成为有用的工具。
