Shaibi Gabriel Q, Faulkner Melissa S, Weigensberg Marc J, Fritschi Cynthia, Goran Michael I
College of Nursing & Healthcare Innovation, Arizona State University, Phoenix, AZ 85004, USA.
Pediatr Diabetes. 2008 Oct;9(5):460-3. doi: 10.1111/j.1399-5448.2008.00407.x. Epub 2008 May 22.
The increased incidence of type 2 diabetes (T2D) among youth is hypothesized to be due, in part, to low levels of fitness and activity. Therefore, the purpose of this investigation was to examine whether cardiorespiratory fitness and physical activity are reduced in youth with T2D compared with overweight controls.
Thirteen adolescent boys with previously diagnosed T2D (mean duration 2.4 +/- 1.8 yr) were matched for age and body mass index to 13 overweight, non-diabetic controls.
Cardiorespiratory fitness was assessed during a progressive exercise test to volitional fatigue and physical activity was estimated from a 7-d physical activity recall.
Youth with T2D reported performing approximately 60% less moderate to vigorous physical activity compared with their non-diabetic counterparts (0.6 +/- 0.2 vs. 1.4 +/- 0.3 h/d, p = 0.04). Furthermore, diabetic youth exhibited significantly lower cardiorespiratory fitness levels compared with controls (28.7 +/- 1.6 vs. 34.6 +/- 2.2 mL/kg/min, p < 0.05).
These findings support the hypothesis that cardiorespiratory fitness and physical activity are reduced in youth with T2D. Whether reduced fitness and activity contributed to the pathophysiology of the disorder cannot be determined from the cross-sectional analysis. Longitudinal studies are warranted to examine whether improvements in fitness and increased physical activity can prevent the development of T2D in high-risk youth.
青少年2型糖尿病（T2D）发病率上升被推测部分归因于健康水平和活动量较低。因此，本研究的目的是检验与超重对照组相比，T2D青少年的心肺适能和身体活动是否降低。
13名先前被诊断为T2D的青春期男孩（平均病程2.4±1.8年），在年龄和体重指数方面与13名超重的非糖尿病对照组相匹配。
通过递增运动试验至自觉疲劳来评估心肺适能，并根据7天身体活动回忆来估计身体活动情况。
与非糖尿病青少年相比，T2D青少年报告的中度至剧烈身体活动量减少了约60%（0.6±0.2 vs. 1.4±0.3小时/天，p = 0.04）。此外，糖尿病青少年的心肺适能水平显著低于对照组（28.7±1.6 vs. 34.6±2.2毫升/千克/分钟，p < 0.05）。
这些发现支持了T2D青少年心肺适能和身体活动降低这一假设。从横断面分析中无法确定适能和活动量降低是否导致了该疾病的病理生理过程。有必要进行纵向研究，以检验适能改善和身体活动增加是否能预防高危青少年发生T2D。
