Motter Arianne L, Ahern Gerard P
Department of Pharmacology, Georgetown University, 3900 Reservoir Road NW, Washington, DC 20007, USA.
FEBS Lett. 2008 Jun 25;582(15):2257-62. doi: 10.1016/j.febslet.2008.05.021. Epub 2008 May 27.
We explored a role for the capsaicin receptor, transient receptor potential channel vanilloid type 1 (TRPV1), in the regulation of feeding and body mass. On a 4.5% fat diet, wild-type and TRPV1-null mice gained equivalent body mass. On an 11% fat diet, however, TRPV1-null mice gained significantly less mass and adiposity; at 44 weeks the mean body weights of wild-type and TRPV1-null mice were approximately 51 and 34g, respectively. Both groups of mice consumed equivalent energy and absorbed similar amounts of lipids. TRPV1-null mice, however, exhibited a significantly greater thermogenic capacity. Interestingly, we found that 3T3-L1 preadipocytes expressed functional calcitonin gene-related peptide receptors. Thus, these data support a potential neurogenic mechanism by which TRPV1-sensitive sensory nerves may regulate energy and fat metabolism.
我们探究了辣椒素受体，即瞬时受体电位香草酸受体1型（TRPV1）在进食和体重调节中的作用。在4.5%脂肪含量的饮食条件下，野生型小鼠和TRPV1基因敲除小鼠体重增加量相当。然而，在11%脂肪含量的饮食条件下，TRPV1基因敲除小鼠的体重和脂肪增加量显著减少；在44周时，野生型小鼠和TRPV1基因敲除小鼠的平均体重分别约为51克和34克。两组小鼠摄入的能量相当，吸收的脂质量也相似。然而，TRPV1基因敲除小鼠表现出显著更强的产热能力。有趣的是，我们发现3T3-L1前脂肪细胞表达功能性降钙素基因相关肽受体。因此，这些数据支持了一种潜在的神经源性机制，即TRPV1敏感的感觉神经可能调节能量和脂肪代谢。
