Muraoka Noriaki, Uematsu Hidemasa, Kimura Hirohiko, Imamura Yoshiaki, Fujiwara Yasuhiro, Murakami Makoto, Yamaguchi Akio, Itoh Harumi
Department of Radiology, University of Fukui, Fukui, Japan.
J Magn Reson Imaging. 2008 Jun;27(6):1302-8. doi: 10.1002/jmri.21340.
To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue.
Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion-weighted (DW) echo-planar imaging (b value = 0, 500 s/mm(2)) was employed to calculate the apparent diffusion coefficient (ADC). ADC values of cancer and noncancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results.
The mean (+/-standard deviation) ADC value was significantly lower for tumor (1.27 +/- 0.52 x 10(-3) mm(2)/s) than for noncancerous tissue (1.90 +/- 0.41 x 10(-3) mm(2)/s, P < 0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis, and mucin in each case. Regarding the density of fibrosis in cancer, three cases were classified in the loose fibrosis group and the remaining seven cases were classified in the dense fibrosis group. The mean ADC value was significantly higher in the loose fibrosis group (1.88 +/- 0.39 x 10(-3) mm(2)/s) than in the dense fibrosis group (1.01 +/- 0.29 x 10(-3) mm(2)/s, P < 0.05). In quantitative analysis, ADC correlated well with the proportion of collagenous fibers (r = -0.87, P < 0.05).
Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer.
明确胰腺癌组织中导致扩散异常的主要成分。
研究对象包括10例经手术确诊的胰腺癌患者。采用扩散加权（DW）回波平面成像（b值 = 0、500 s/mm²）计算表观扩散系数（ADC）。计算癌组织和非癌组织的ADC值。此外，将癌组织的ADC值与组织病理学结果进行比较。
肿瘤组织的平均（±标准差）ADC值（1.27 ± 0.52×10⁻³ mm²/s）显著低于非癌组织（1.90 ± 0.41×10⁻³ mm²/s，P < 0.05）。组织病理学检查显示，每例中纤维化区域、细胞成分、坏死和黏液的比例相似。关于癌组织中纤维化的密度，3例被归类为疏松纤维化组，其余7例被归类为致密纤维化组。疏松纤维化组的平均ADC值（1.88 ± 0.39×10⁻³ mm²/s）显著高于致密纤维化组（1.01 ± 0.29×10⁻³ mm²/s，P < 0.05）。在定量分析中，ADC与胶原纤维比例相关性良好（r = -0.87，P < 0.05）。
胶原纤维可能是胰腺癌扩散异常的原因。
