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Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants.Eaf1是NuA4分子组装的平台，在进化上它将染色质乙酰化与组蛋白H2A变体的ATP依赖型交换联系起来。
Mol Cell Biol. 2008 Apr;28(7):2257-70. doi: 10.1128/MCB.01755-07. Epub 2008 Jan 22.
2
Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.微小染色体维持蛋白与检查点蛋白和重组蛋白相互作用，以促进S期基因组稳定性。
Mol Cell Biol. 2008 Mar;28(5):1724-38. doi: 10.1128/MCB.01717-07. Epub 2008 Jan 7.
3
New nomenclature for chromatin-modifying enzymes.染色质修饰酶的新命名法。
Cell. 2007 Nov 16;131(4):633-6. doi: 10.1016/j.cell.2007.10.039.
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Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe.Msc1通过组蛋白H2A.Z发挥作用，以促进粟酒裂殖酵母中的染色体稳定性。
Genetics. 2007 Nov;177(3):1487-97. doi: 10.1534/genetics.107.078691. Epub 2007 Oct 18.
5
Epigenetic control of centromere behavior.着丝粒行为的表观遗传调控。
Annu Rev Genet. 2007;41:63-81. doi: 10.1146/annurev.genet.41.110306.130127.
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MYST opportunities for growth control: yeast genes illuminate human cancer gene functions.MYST家族在生长调控方面的机遇：酵母基因揭示人类癌症基因功能
Oncogene. 2007 Aug 13;26(37):5373-84. doi: 10.1038/sj.onc.1210606.
7
Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation.Tip60组蛋白乙酰转移酶通过乙酰化作用作为Notch1信号通路的负调节因子。
Mol Cell Biol. 2007 Sep;27(18):6506-19. doi: 10.1128/MCB.01515-06. Epub 2007 Jul 16.
8
The plant homeodomain fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity.裂殖酵母Msc1的植物同源结构域指具有E3泛素连接酶活性。
J Biol Chem. 2007 Jun 22;282(25):18397-18406. doi: 10.1074/jbc.M700729200. Epub 2007 Apr 24.
9
Interplay of replication checkpoints and repair proteins at stalled replication forks.停滞复制叉处复制检查点与修复蛋白的相互作用。
DNA Repair (Amst). 2007 Jul 1;6(7):994-1003. doi: 10.1016/j.dnarep.2007.02.018. Epub 2007 Mar 26.
10
Histone acetyltransferase complexes: one size doesn't fit all.组蛋白乙酰转移酶复合物：并非一概而论。
Nat Rev Mol Cell Biol. 2007 Apr;8(4):284-95. doi: 10.1038/nrm2145.

粟酒裂殖酵母组蛋白乙酰转移酶Mst1（KAT5）是损伤应答和染色体分离所必需的一种重要蛋白质。

Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.

作者信息

Gómez Eliana B, Nugent Rebecca L, Laria Sebastián, Forsburg Susan L

机构信息

Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 90089-2910, USA.

出版信息

Genetics. 2008 Jun;179(2):757-71. doi: 10.1534/genetics.107.085779. Epub 2008 May 27.

DOI:10.1534/genetics.107.085779
PMID:18505873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2429872/
Abstract

Schizosaccharomyces pombe Mst1 is a member of the MYST family of histone acetyltransferases and is the likely ortholog of Saccharomyces cerevisiae Esa1 and human Tip60 (KAT5). We have isolated a temperature-sensitive allele of this essential gene. mst1 cells show a pleiotropic phenotype at the restrictive temperature. They are sensitive to a variety of DNA-damaging agents and to the spindle poison thiabendazole. mst1 has an increased frequency of Rad22 repair foci, suggesting endogenous damage. Two-hybrid results show that Mst1 interacts with a number of proteins involved in chromosome integrity and centromere function, including the methyltransferase Skb1, the recombination mediator Rad22 (Sc Rad52), the chromatin assembly factor Hip1 (Sc Hir1), and the Msc1 protein related to a family of histone demethylases. mst1 mutant sensitivity to hydroxyurea suggests a defect in recovery following HU arrest. We conclude that Mst1 plays essential roles in maintenance of genome stability and recovery from DNA damage.

摘要

粟酒裂殖酵母Mst1是组蛋白乙酰转移酶MYST家族的成员，可能是酿酒酵母Esa1和人类Tip60（KAT5）的直系同源物。我们分离出了这个必需基因的一个温度敏感等位基因。mst1细胞在限制温度下表现出多效性表型。它们对多种DNA损伤剂和纺锤体毒物噻苯咪唑敏感。mst1的Rad22修复位点频率增加，表明存在内源性损伤。双杂交结果表明，Mst1与许多参与染色体完整性和着丝粒功能的蛋白质相互作用，包括甲基转移酶Skb1、重组介质Rad22（Sc Rad52）、染色质组装因子Hip1（Sc Hir1）以及与组蛋白去甲基酶家族相关的Msc1蛋白。mst1突变体对羟基脲的敏感性表明在HU阻滞恢复过程中存在缺陷。我们得出结论，Mst1在维持基因组稳定性和从DNA损伤中恢复方面发挥着重要作用。