Windfuhr J P, Schloendorff G, Baburi D, Kremer B
Department of Otorhinolaryngology, Head and Neck Surgery, Malteser Krankenhaus St. Anna, Albertus Magnus Str. 33, 47259, Duisburg, Germany.
Eur Arch Otorhinolaryngol. 2008 Dec;265(12):1527-34. doi: 10.1007/s00405-008-0699-4. Epub 2008 May 28.
Despite the large number of tonsillectomies performed little knowledge exists about post-tonsillectomy hemorrhage (PTH) with lethal outcome. This study was performed to evaluate clinical features in a larger patient population with emphasis on the onset of this complication. A nationwide collection of cases was performed based on personal communication, expert reports to lawsuits and professional boards, and case reports received after a plea published in a professional national journal. Clinical data of 29 patients were collected of whom the 18 were children (64%). With one exception all patients experienced secondary PTH (>24 h) occurring 1-28 days after tonsillectomy. Aspiration contributed to lethal outcome in 13 cases. Fatalities were unavoidable although 21 patients were in the hospital. Massive vomiting of blood was observed in 11 patients. There were 11 patients without (group A) and 18 with (group B) episodes of repeated bleeding. This study suggests that particularly children are endangered by lethal PTH. Inpatient treatment was unable to prevent lethal outcome in this selected patient population. However, it appears wise to re-admit patients with delayed PTH, since excessive PTH may occur. These unexpected and unpredictable situations require an immediate and adequate medical treatment by a skilled staff. The paucity of data currently does not allow calculation of a cut-off point at which the risk of life-threatening PTH significantly decreases. Secondary PTH remains a substantial complication.
尽管扁桃体切除术的实施数量众多,但对于导致致命后果的扁桃体切除术后出血(PTH)却知之甚少。本研究旨在评估更多患者群体的临床特征,重点关注这一并发症的发病情况。通过个人交流、专家向诉讼和专业委员会提交的报告以及在一份专业国家期刊上发表呼吁后收到的病例报告,进行了全国范围的病例收集。收集了29例患者的临床数据,其中18例为儿童(64%)。除1例例外,所有患者均经历了扁桃体切除术后1 - 28天发生的继发性PTH(>24小时)。13例患者的死亡与误吸有关。尽管21例患者住院治疗,但死亡仍不可避免。11例患者出现大量吐血。11例患者未出现(A组)反复出血情况,18例患者出现(B组)反复出血情况。本研究表明,尤其是儿童易受致命性PTH的威胁。在这一特定患者群体中,住院治疗无法预防致命后果。然而,鉴于可能出现迟发性PTH,重新收治此类患者似乎是明智之举。这些意外且不可预测的情况需要由技术熟练的人员立即进行充分的医疗救治。目前数据匮乏,无法计算出危及生命的PTH风险显著降低的临界点。继发性PTH仍然是一种严重并发症。