Axmon Anna, Rylander Lars, Rignell-Hydbom Anna
Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, University Hospital, SE-221 85 Lund, Sweden.
Environ Health. 2008 May 28;7:20. doi: 10.1186/1476-069X-7-20.
Cohorts comprising fishermen's families on the east coast of Sweden have been found to have a high consumption of contaminated fish as well as high body burdens of persistent organochlorine pollutants (POPs). Their west coast correspondents are socio-economically similar, but with considerably lower POP exposure since the fish caught on the west coast is far less contaminated. The rationale for this was that the cohorts residing on the east coast of Sweden have been found to have a high consumption of contaminated fish as well as high body burdens of POPs, whereas their west coast correspondents are socio-economically similar, but with considerably lower POP exposure since the fish caught on the west coast is far less contaminated. Among the reproductive outcomes investigated are included both male and female parameters, as well as couple fertility and effects on the fetus. A range of exposure measures, including both questionnaire assessments of fish consumption and biomarkers, have been used. The most consistent findings of the studies are those related to the fetus, where a decreased birth weight was found across all measures of exposure, which is in agreement with studies from other populations. Some markers for male reproduction function, i.e. sperm motility, sperm chromatin integrity, and Y:X chromosome ratio, were associated with POP exposure, whereas others, such as sperm concentration and semen volume, were not. With respect to couple fertility and female reproductive parameters, no support was given for associations with POP exposure. Although some associations may have been affected by beneficial effects of essential nutrients in seafood, the overall findings are meaningful in the context of reproductive toxicity and support the usefulness of the epidemiological design.
瑞典东海岸渔民家庭队列被发现食用受污染鱼类的量很高，体内持久性有机氯污染物（POPs）的负荷也很高。其西海岸的对应人群在社会经济方面与之相似，但由于西海岸捕获的鱼类受污染程度低得多，他们接触POPs的量要低得多。这样做的理由是，居住在瑞典东海岸的队列被发现食用受污染鱼类的量很高，体内POPs的负荷也很高，而其西海岸的对应人群在社会经济方面与之相似，但由于西海岸捕获的鱼类受污染程度低得多，他们接触POPs的量要低得多。在调查的生殖结局中，包括男性和女性参数，以及夫妇生育力和对胎儿的影响。已经使用了一系列暴露测量方法，包括对鱼类消费的问卷调查评估和生物标志物。这些研究最一致的发现是与胎儿有关的发现，在所有暴露测量中都发现出生体重下降，这与其他人群的研究结果一致。一些男性生殖功能指标，即精子活力、精子染色质完整性和Y:X染色体比率，与POPs暴露有关，而其他指标，如精子浓度和精液量，则无关。关于夫妇生育力和女性生殖参数，没有证据支持与POPs暴露有关。尽管一些关联可能受到海鲜中必需营养素的有益影响，但总体研究结果在生殖毒性方面是有意义的，并支持了流行病学设计的实用性。
