Axmon Anna
Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, Department of Laboratory Medicine, Lund University, University Hospital, SE-221 85 Lund, Sweden.
Environ Res. 2006 Sep;102(1):77-82. doi: 10.1016/j.envres.2005.12.014. Epub 2006 Feb 2.
In animal studies, exposure to persistent organochlorine pollutants (POPs) in utero and through mother's milk has been suggested to affect the onset of puberty. However, human studies are scarce and ambiguous. In the present study, information on age at menarche was collected from 545 women who had been brought up in a fishing village/family on the Swedish east coast, off the Baltic Sea, and therefore were assumed to have been exposed to POPs in utero, through breast feeding, and/or through dietary habits during their childhood. The average age at menarche for these women was compared to that of three referent groups: (a) 1252 women who also had been brought up in a fishing village/family, but on the Swedish west coast, where the fish had been considerably less contaminated; (b) 634 women from the east coast, but who had not grown up in a fishing village/family; and (c) 869 women from the west coast who had not grown up in a fishing village/family. Based on previous studies, all groups were regarded as having similar socioeconomic circumstances. Data were analyzed using analysis of variance (ANOVA). In an attempt to account for variations in environmental concentrations of POPs over time, all analyses were adjusted for year of birth. Exposed women were found to be slightly older at menarche than referent women from the same coastal area (mean age 13.0 vs 12.8 yr). No differences were found between the exposed women and the two other referent groups (mean age 13.0 yr in all groups).
在动物研究中，有观点认为子宫内接触持久性有机氯污染物（POPs）以及通过母乳接触这些污染物会影响青春期的开始。然而，人体研究却很稀少且结果不明确。在本研究中，从545名在瑞典东海岸波罗的海沿岸渔村/渔民家庭长大的女性中收集了初潮年龄信息，因此假定她们在童年时期通过子宫内接触、母乳喂养和/或饮食习惯接触到了POPs。将这些女性的平均初潮年龄与三个参照组进行比较：（a）1252名同样在渔村/渔民家庭长大，但在瑞典西海岸的女性，那里的鱼类受污染程度要低得多；（b）634名来自东海岸但并非在渔村/渔民家庭长大的女性；以及（c）869名来自西海岸且并非在渔村/渔民家庭长大的女性。基于之前的研究，所有组都被视为具有相似的社会经济状况。使用方差分析（ANOVA）对数据进行分析。为了考虑POPs环境浓度随时间的变化，所有分析都根据出生年份进行了调整。结果发现，接触POPs的女性初潮年龄比来自同一沿海地区的参照女性略大（平均年龄13.0岁对12.8岁）。在接触POPs的女性与其他两个参照组之间未发现差异（所有组的平均年龄均为13.0岁）。
