Khanjani Narges, Sim Malcolm Ross
Monash Centre for Occupational & Environmental Health, Department of Epidemiology & Preventive Medicine (Monash University), The Alfred Hospital, Melbourne, VIC, Australia.
J Expo Sci Environ Epidemiol. 2007 Mar;17(2):191-5. doi: 10.1038/sj.jes.7500495. Epub 2006 Jun 14.
Polychlorinated biphenyls used previously in industry are widespread environmental contaminants under scrutiny for their possible reproductive effects in humans. In this study, 200 breast milk samples from eligible Victorian mothers were used for measuring maternal contamination and their possible effect on the offspring was investigated. No significant association was found between maternal PCB contamination and low birth weight, small for gestational age and previous miscarriage or stillbirth. The elevated odd ratios of prematurity, increased with increase in contamination level but were nonsignificant. Higher PCB contamination was not in favor of any gender in the offspring. Our results suggest that chronic, low contamination with PCBs does not pose a reproduction threat in humans.
以前在工业中使用的多氯联苯是受到密切关注的广泛存在的环境污染物，因为它们可能对人类生殖产生影响。在本研究中，选取了200份来自符合条件的维多利亚州母亲的母乳样本，用于测量母亲体内的污染物含量，并研究其对后代可能产生的影响。未发现母亲多氯联苯污染与低出生体重、小于胎龄以及既往流产或死产之间存在显著关联。早产的优势比虽随污染水平升高而增加，但无统计学意义。较高的多氯联苯污染对后代的任何性别均无偏好。我们的结果表明，多氯联苯的慢性低水平污染不会对人类生殖构成威胁。
