Redmond Kelly Marie, Wilson Timothy Richard, Johnston Patrick Gerard, Longley Daniel Broderick
Drug Resistance Laboratory, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.
Front Biosci. 2008 May 1;13:5138-54. doi: 10.2741/3070.
Resistance to chemotherapy ('drug resistance') is a fundamental problem that limits the effectiveness of many chemotherapies currently used to treat cancer. Drug resistance can occur due to a variety of mechanisms, such as increased drug inactivation, drug efflux from cancer cells, enhanced repair of chemotherapy-induced damage, activation of pro-survival pathways and inactivation of cell death pathways. In this article, we review some of the major mechanisms of drug resistance and discuss how new molecularly-targeted therapies are being increasingly used to overcome these resistance mechanisms.
化疗耐药性（“耐药性”）是一个根本性问题，它限制了目前用于治疗癌症的许多化疗方法的有效性。耐药性可能由于多种机制而产生，例如药物失活增加、癌细胞排出药物、化疗诱导损伤的修复增强、促生存途径的激活以及细胞死亡途径的失活。在本文中，我们回顾了一些主要的耐药机制，并讨论了新型分子靶向疗法如何越来越多地用于克服这些耐药机制。
