Chuah Khoon Leong, Ng Siok Bian, Poon Limei, Yap Wai Ming
Department of Pathology Tan Tock Seng Hospital, Singapore.
Int J Surg Pathol. 2009 Apr;17(2):163-6. doi: 10.1177/1066896908316785. Epub 2008 May 28.
Plasmablastic lymphoma is a rare variant of a diffuse, large B-cell lymphoma, which typically presents in the oral cavity in immunocompromised patients. In HIV positive patients, this tumor has a tendency to manifest in extramedullary sites. In this report, we document a rare instance in which this neoplasm besides affecting the bone marrow also involved the lung. In addition, the lymphoma in our case disclosed CD10 positivity on immunohistochemistry and t(8;14)(q24;q34) translocation on cytogenetic analysis, mimicking a Burkitt/atypical Burkitt lymphoma. The problems in diagnosis are discussed.
浆母细胞性淋巴瘤是弥漫性大B细胞淋巴瘤的一种罕见变异型，通常发生于免疫功能低下患者的口腔。在HIV阳性患者中，这种肿瘤倾向于在髓外部位表现出来。在本报告中，我们记录了一个罕见病例，该肿瘤除累及骨髓外还侵犯了肺。此外，我们病例中的淋巴瘤在免疫组化上显示CD10阳性，细胞遗传学分析显示t(8;14)(q24;q34)易位，酷似伯基特淋巴瘤/非典型伯基特淋巴瘤。文中讨论了诊断方面的问题。
