de Jonge Lise T, Leeuwenburgh Sander C G, Wolke Joop G C, Jansen John A
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, THK-309-PB, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Pharm Res. 2008 Oct;25(10):2357-69. doi: 10.1007/s11095-008-9617-0. Epub 2008 May 29.
This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.
本文综述了目前为增强钛植入材料界面处骨再生而研究的物理化学和生物化学涂层技术。通过在钛表面施加模拟活骨组织有机和无机成分的涂层，可以在非生理性钛表面和周围骨组织之间建立生理过渡。这样，涂覆的钛植入物可刺激植入物表面的骨形成，从而增强骨替代植入物的早期牢固固定。因此，诱导了从骨组织到植入物表面的连续过渡。本综述概述了可用于此目的的各种技术，这些技术受到天然骨组织的无机（磷酸钙）或有机（细胞外基质成分、生长因子、酶等）成分的启发。然而，有机和无机成分的结合有望产生真正类似骨的涂层，从而产生具有改进功能和生物功效的新一代表面改性钛植入物。
