University Centre for Orthopaedics and Trauma Surgery, University Hospital Carl Gustav Carus Dresden, Dresden, Germany.
Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Faculty of Medicine of Technische Universität Dresden, Dresden, Germany.
J Biomed Mater Res B Appl Biomater. 2020 Apr;108(3):1117-1128. doi: 10.1002/jbm.b.34463. Epub 2019 Aug 12.
For cementless total joint replacement implants, the biological response to physicochemical surface characteristics is crucial for their success that depends on fixation by newly formed bone. In this study, the surface of TiAl6V4 (Tilastan®) implants was modified by (a) corundum blasting, (b) corundum blasting followed by electrochemical calcium phosphate (CaP) deposition, and (c) titanium plasma spraying followed by electrochemical CaP deposition. All modifications resulted in a surface roughness suitable to enhance primary implant stabilization and to favor osteoblast adhesion and function; the thin, biomimetic CaP coating is characterized by fast resorbability and served as chemical cue to stimulate osteogenesis. After implantation in a full weight-bearing rabbit intramedullary distal femur model, osseointegration was investigated after 3, 6, and 12 weeks. For all modifications, new bone formation, occurring from the endosteum of the femoral cortical bone, was observed in direct contact to the implant surface after 3 weeks. At the later time points, maturation of the woven bone into lamellar bone with clearly defined osteons was visible; the remodeling process was accelerated by the CaP coating. The ingrowth of newly formed bone into the pores of the titanium plasma sprayed surfaces indicates a strong interlock and finally implant fixation. Our findings indicate a positive impact of the tested surface modifications on osseointegration.
对于无水泥全关节置换植入物，其理化表面特性对其成功的生物学反应至关重要，这取决于新形成的骨的固定。在这项研究中，TiAl6V4（Tilastan®）植入物的表面通过（a）刚玉喷砂、（b）刚玉喷砂后进行电化学磷酸钙（CaP）沉积和（c）钛等离子喷涂后进行电化学 CaP 沉积进行了改性。所有的改性都导致了合适的表面粗糙度，以增强初始植入物的稳定性，并有利于成骨细胞的黏附和功能；薄的、仿生 CaP 涂层具有快速的可吸收性，并作为化学信号刺激成骨。在全负重兔髓内股骨远端模型中植入后，在 3、6 和 12 周时研究了骨整合情况。对于所有的改性，在 3 周时，在股骨皮质骨的骨内膜处观察到新骨形成，与植入物表面直接接触。在后期时间点，编织骨成熟为具有明确定义的骨单位的板层骨；CaP 涂层加速了重塑过程。新形成的骨向内生长到钛等离子喷涂表面的孔隙中，表明具有很强的互锁作用，最终实现了植入物的固定。我们的研究结果表明，所测试的表面改性对骨整合有积极影响。
