Wang Tingting, Zhu Yi, Zheng Yuanzhu, Cao Yang, Xu Qin, Wang Xiangan, Hu Wenli, Zhang Yun
Department of Nutrition, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Communicable Diseases Control and Prevention, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Front Nutr. 2022 Dec 8;9:1015062. doi: 10.3389/fnut.2022.1015062. eCollection 2022.
Epidemiological studies provide limited information on the relationship between dairy consumption and the incidence of esophagus cancer (EC). We examined whether eating dairy foods is associated with a lower risk of EC in an American population.
In our study, we analyzed data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial, which included 101,723 subjects. Dairy product consumption was assessed using a dietary history questionnaire. We used Cox regression and restricted cubic splines to assess whether dairy consumption is associated with EC incidence.
A total of 154 EC cases were identified after a median follow-up of 12.2 years. After adjusting for confounders, we discovered no statistically significant correlation between total dairy product consumption and EC risk (HR with 95% CI for ≥1.79 servings/day vs. ≤0.6 servings/day: 0.83, 0.50-1.38; for trend = 0.465). Additionally, no associations were found between EC risk and other dairy foods such as milk, yogurt, and cheese.
We concluded that the findings of the PLCO cohort do not suggest dairy consumption reduces the risk of EC.
流行病学研究提供了关于乳制品消费与食管癌（EC）发病率之间关系的有限信息。我们研究了在美国人群中食用乳制品是否与较低的EC风险相关。
在我们的研究中，我们分析了前列腺、肺、结肠和卵巢（PLCO）癌症筛查试验的数据，该试验包括101,723名受试者。使用饮食史问卷评估乳制品消费情况。我们使用Cox回归和受限立方样条来评估乳制品消费是否与EC发病率相关。
在中位随访12.2年后，共确定了154例EC病例。在调整混杂因素后，我们发现总乳制品消费与EC风险之间无统计学显著相关性（每天≥1.79份与≤0.6份相比的HR及95%CI：0.83，0.50 - 1.38；趋势P = 0.465）。此外，未发现EC风险与其他乳制品如牛奶、酸奶和奶酪之间存在关联。
我们得出结论，PLCO队列的研究结果并不表明乳制品消费可降低EC风险。
