抗蛋白酶抑制肽及其他非天然盐孢菌素蛋白酶体抑制剂的工程化生物合成。
Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors.
作者信息
McGlinchey Ryan P, Nett Markus, Eustáquio Alessandra S, Asolkar Ratnakar N, Fenical William, Moore Bradley S
机构信息
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA.
出版信息
J Am Chem Soc. 2008 Jun 25;130(25):7822-3. doi: 10.1021/ja8029398. Epub 2008 May 31.
Abstract
A new shunt in the phenylalanine biosynthetic pathway to the nonproteinogenic amino acid L-3-cyclohex-2'-enylalanine was exploited in the marine bacterium Salinispora tropica by mutagenesis to allow for the genetic engineering of unnatural derivatives of the potent proteasome inhibitor salinosporamide A (2) such as antiprotealide (1).
摘要
通过诱变在热带盐孢菌中利用苯丙氨酸生物合成途径中的一个新分支，使其生成非蛋白质氨基酸L-3-环己-2'-烯基丙氨酸，从而对强效蛋白酶体抑制剂盐孢菌素A（2）的非天然衍生物（如抗蛋白酶体化合物（1））进行基因工程改造。
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