雌二醇诱导的物体记忆巩固增强涉及雌性C57BL/6小鼠背侧海马中的NMDA受体和蛋白激酶A。
Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice.
作者信息
Lewis Michael C, Kerr Kristin M, Orr Patrick T, Frick Karyn M
机构信息
Department of Psychology, Yale University, USA.
出版信息
Behav Neurosci. 2008 Jun;122(3):716-21. doi: 10.1037/0735-7044.122.3.716.
Abstract
This study examined the role of dorsal hippocampal NMDA receptors and PKA activation in 17 beta-estradiol (E2)-induced enhancement of object memory consolidation. Mice explored two identical objects during training, after which they immediately received intraperitoneal injections of 0.2 mg/kg E2, and bilateral dorsal hippocampal infusions of Vehicle, the NMDA receptor antagonist APV (2.5 microg/side), or the cAMP inhibitor Rp-cAMPS (18.0 microg/side). Retention was tested 48 hours later. The enhanced object memory and increased ERK phosphorylation observed with E2 alone was reduced by APV and Rp-cAMPS, suggesting that estrogenic enhancement of object memory involves NMDA receptors and PKA activation within the dorsal hippocampus.
摘要
本研究考察了背侧海马N-甲基-D-天冬氨酸（NMDA）受体及蛋白激酶A（PKA）激活在17β-雌二醇（E2）诱导增强物体记忆巩固中的作用。小鼠在训练期间探索两个相同的物体，之后立即腹腔注射0.2mg/kg E2，并双侧背侧海马注射溶媒、NMDA受体拮抗剂APV（2.5μg/侧）或环磷酸腺苷（cAMP）抑制剂Rp-cAMPS（18.0μg/侧）。48小时后测试记忆保持情况。单独使用E2时观察到的物体记忆增强及细胞外信号调节激酶（ERK）磷酸化增加，被APV和Rp-cAMPS减弱，这表明雌激素对物体记忆的增强作用涉及背侧海马内的NMDA受体及PKA激活。
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