C1与人类血小板。III. C1亚成分在聚集的IgG诱导的血小板聚集中的作用。
C1 and human platelets. III. Role of C1 subcomponents in platelet aggregation induced by aggregated IgG.
作者信息
Wautier J L, Souchon H, Solal L C, Peltier A P, Caen J P
出版信息
Immunology. 1976 Oct;31(4):595-9.
Studies have been performed with platelets using C1 haemolytic assays and platelet aggregation induced by anti-C1q, anti-C1s and aggregated IgG in the presence of C1 subcomponents C1q, C1r and C1s. C1q was removed by EDTA or modified by collagenase from human platelets while after the same treatment C1s remained bound to the platelets. EDTA treated platelets were no longer aggregated by aggregated IgG. The addition of C1q restored the reactivity of the platelets to aggregated IgG while the addition of C1r or C1s was without effect. Furthermore, the addition of C1r or C1s to C1q inhibited the action of C1q in platelet aggregation induced by IgG.The possible association between the different C1 subcomponents and human platelets is discussed.
已经使用C1溶血测定法对血小板进行了研究，并在存在C1亚成分C1q、C1r和C1s的情况下，研究了抗C1q、抗C1s和聚集的IgG诱导的血小板聚集。通过EDTA从人血小板中去除C1q或用胶原酶对其进行修饰，而在相同处理后，C1s仍与血小板结合。经EDTA处理的血小板不再被聚集的IgG聚集。添加C1q可恢复血小板对聚集IgG的反应性，而添加C1r或C1s则无作用。此外，向C1q中添加C1r或C1s可抑制C1q在IgG诱导的血小板聚集中的作用。讨论了不同C1亚成分与人类血小板之间可能的关联。
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