正常人血清循环免疫复合物中血小板同种抗原（PlA1）的鉴定。

Identification of the platelet alloantigen (PlA1) in circulating immune complexes of normal human sera.

作者信息

Wautier J L, Boizard B, Doan R, Caen J P, Hartmann L

出版信息

Cancer Immunol Immunother. 1982;13(1):44-7. doi: 10.1007/BF00200199.

DOI:10.1007/BF00200199

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11039217/

Abstract

An analysis of cell membrane material present in circulating immune complexes isolated from normal human sera by precipitation with polyethylene glycol (PEG) has been performed with the platelet alloantigen PlA1 and rhesus antigen used as markers. PEG precipitates obtained from the sera of subjects of known PlA1 and rhesus phenotype were resuspended in buffer and analyzed as representative of circulating immune complexes (CIC). The consumption of anti-PlA1 serum by CIC was determined by immunofluorescence and by inhibition of sodium 51chromate release from PlA1-positive target platelets. With these two techniques, PlA1 alloantigen activity was detected in CIC. This finding suggests that at least some of the cell membrane material present in CIC is derived from platelets.

摘要

利用血小板同种抗原PlA1和恒河猴抗原作为标志物，对通过聚乙二醇（PEG）沉淀从正常人血清中分离出的循环免疫复合物中的细胞膜物质进行了分析。从已知PlA1和恒河猴血型表型的受试者血清中获得的PEG沉淀物重悬于缓冲液中，并作为循环免疫复合物（CIC）的代表进行分析。通过免疫荧光和抑制51铬酸钠从PlA1阳性靶血小板的释放来测定CIC对抗PlA1血清的消耗。通过这两种技术，在CIC中检测到了PlA1同种抗原活性。这一发现表明，CIC中存在的至少一些细胞膜物质源自血小板。

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Cancer Immunol Immunother. 1982;13(1):44-7. doi: 10.1007/BF00200199.

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本文引用的文献

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Detection of circulating immune complexes in human sera by simplified assays with polyethylene glycol.用聚乙二醇简化分析法检测人血清中的循环免疫复合物

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C1 and human platelets. II. Detection by immunological methods and role.C1与人类血小板。II. 免疫学方法检测及其作用

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Posttransfusional immunologic thrombocytopenia. A case report.输血后免疫性血小板减少症。病例报告。

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Deletion of the platelet-specific alloantigen PlA1 from platelets in Glanzmann's thrombasthenia.在Glanzmann血小板无力症中血小板特异性同种抗原PlA1从血小板上缺失。

J Clin Invest. 1978 May;61(5):1225-31. doi: 10.1172/JCI109038.

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