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1
Identification of the platelet alloantigen (PlA1) in circulating immune complexes of normal human sera.正常人血清循环免疫复合物中血小板同种抗原（PlA1）的鉴定。
Cancer Immunol Immunother. 1982;13(1):44-7. doi: 10.1007/BF00200199.
2
Serological and biochemical analysis of the PlA1 alloantigen of human platelets.人血小板PlA1同种抗原的血清学和生化分析。
Br J Haematol. 1982 Feb;50(2):351-9. doi: 10.1111/j.1365-2141.1982.tb01926.x.
3
The platelet alloantigen Zwa or PlA1 is expressed by cultured endothelial cells.血小板同种抗原Zwa或PlA1由培养的内皮细胞表达。
Br J Haematol. 1987 Jul;66(3):369-73. doi: 10.1111/j.1365-2141.1987.tb06925.x.
4
Analysis of antigen involved in circulating immune complexes in patients with idiopathic thrombocytopenic purpura.特发性血小板减少性紫癜患者循环免疫复合物中相关抗原的分析。
Clin Exp Immunol. 1987 Feb;67(2):293-9.
5
Inheritance of the human platelet alloantigen, PlA1, in type I Glanzmann's thrombasthenia.I型Glanzmann血小板无力症中人类血小板同种抗原PlA1的遗传
J Clin Invest. 1981 Mar;67(3):717-24. doi: 10.1172/JCI110088.
6
Posttransfusion purpura: conversion of PLA1-negative platelets to the PLA1-positive phenotype by stored plasma is not due to the presence of soluble PLA1 antigen.输血后紫癜：储存血浆将PLA1阴性血小板转变为PLA1阳性表型并非由于可溶性PLA1抗原的存在。
Proc Soc Exp Biol Med. 1990 Nov;195(2):192-6. doi: 10.3181/00379727-195-43133.
7
Immunochemical characterization of the platelet-specific alloantigen Leka: a comparative study with the PlA1 alloantigen.血小板特异性同种抗原Leka的免疫化学特性：与PlA1同种抗原的比较研究。
Blood. 1984 Dec;64(6):1212-9.
8
On the association of the platelet-specific alloantigen, Pena, with glycoprotein IIIa. Evidence for heterogeneity of glycoprotein IIIa.关于血小板特异性同种抗原Pena与糖蛋白IIIa的关联。糖蛋白IIIa异质性的证据。
J Clin Invest. 1987 Dec;80(6):1624-30. doi: 10.1172/JCI113250.
9
Evaluation of platelet surface antigens: localization of the PlA1 alloantigen.血小板表面抗原的评估：PlA1同种抗原的定位
Br J Haematol. 1982 Jun;51(2):297-304.
10
Quantitative determination of platelet surface alloantigens using a monoclonal probe.使用单克隆探针定量测定血小板表面同种抗原。
Hum Immunol. 1986 Mar;15(3):251-62. doi: 10.1016/0198-8859(86)90001-7.

本文引用的文献

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A new test for the detection of weak and incomplete Rh agglutinins.一种用于检测弱和不完全Rh凝集素的新测试。
Br J Exp Pathol. 1945;26(4):255-66.
2
IMMUNOREACTIONS INVOLVING PLATELETS. V. POST-TRANSFUSION PURPURA DUE TO A COMPLEMENT-FIXING ANTIBODY AGAINST A GENETICALLY CONTROLLED PLATELET ANTIGEN. A PROPOSED MECHANISM FOR THROMBOCYTOPENIA AND ITS RELEVANCE IN "AUTOIMMUNITY".涉及血小板的免疫反应。五、由针对遗传控制的血小板抗原的补体结合抗体引起的输血后紫癜。血小板减少症的一种推测机制及其在“自身免疫”中的相关性。
J Clin Invest. 1961 Sep;40(9):1597-620. doi: 10.1172/JCI104383.
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A platelet and granulocyte membrane defect in paroxysmal nocturnal hemoglobinuria: usefulness for the detection of platelet antibodies.阵发性夜间血红蛋白尿中的血小板和粒细胞膜缺陷：对检测血小板抗体的作用。
J Clin Invest. 1969 Jul;48(7):1199-210. doi: 10.1172/JCI106084.
4
Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol.通过聚乙二醇沉淀法检测抗体和可溶性抗原-抗体复合物。
J Immunol. 1973 Oct;111(4):1219-27.
5
The effects of immune complexes on blood platelets and their relationship to complement activation.免疫复合物对血小板的影响及其与补体激活的关系。
Immunochemistry. 1972 Nov;9(11):1151-65. doi: 10.1016/0019-2791(72)90085-7.
6
Precipitin reactions of the C1q component of complement with aggregated gamma-globulin and immune complexes in gel diffusion.补体C1q成分在凝胶扩散中与聚集的γ-球蛋白及免疫复合物的沉淀素反应。
Immunology. 1970 Dec;19(6):909-19.
7
Detection of circulating immune complexes in human sera by simplified assays with polyethylene glycol.用聚乙二醇简化分析法检测人血清中的循环免疫复合物
J Immunol Methods. 1977;16(2):165-83. doi: 10.1016/0022-1759(77)90051-5.
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C1 and human platelets. II. Detection by immunological methods and role.C1与人类血小板。II. 免疫学方法检测及其作用
Immunology. 1976 Apr;30(4):459-65.
9
Posttransfusional immunologic thrombocytopenia. A case report.输血后免疫性血小板减少症。病例报告。
Vox Sang. 1979;37(1):21-9. doi: 10.1111/j.1423-0410.1979.tb02264.x.
10
Deletion of the platelet-specific alloantigen PlA1 from platelets in Glanzmann's thrombasthenia.在Glanzmann血小板无力症中血小板特异性同种抗原PlA1从血小板上缺失。
J Clin Invest. 1978 May;61(5):1225-31. doi: 10.1172/JCI109038.

正常人血清循环免疫复合物中血小板同种抗原（PlA1）的鉴定。

Identification of the platelet alloantigen (PlA1) in circulating immune complexes of normal human sera.

作者信息

Wautier J L, Boizard B, Doan R, Caen J P, Hartmann L

出版信息

Cancer Immunol Immunother. 1982;13(1):44-7. doi: 10.1007/BF00200199.

DOI:10.1007/BF00200199
PMID:6760957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11039217/
Abstract

An analysis of cell membrane material present in circulating immune complexes isolated from normal human sera by precipitation with polyethylene glycol (PEG) has been performed with the platelet alloantigen PlA1 and rhesus antigen used as markers. PEG precipitates obtained from the sera of subjects of known PlA1 and rhesus phenotype were resuspended in buffer and analyzed as representative of circulating immune complexes (CIC). The consumption of anti-PlA1 serum by CIC was determined by immunofluorescence and by inhibition of sodium 51chromate release from PlA1-positive target platelets. With these two techniques, PlA1 alloantigen activity was detected in CIC. This finding suggests that at least some of the cell membrane material present in CIC is derived from platelets.

摘要

利用血小板同种抗原PlA1和恒河猴抗原作为标志物，对通过聚乙二醇（PEG）沉淀从正常人血清中分离出的循环免疫复合物中的细胞膜物质进行了分析。从已知PlA1和恒河猴血型表型的受试者血清中获得的PEG沉淀物重悬于缓冲液中，并作为循环免疫复合物（CIC）的代表进行分析。通过免疫荧光和抑制51铬酸钠从PlA1阳性靶血小板的释放来测定CIC对抗PlA1血清的消耗。通过这两种技术，在CIC中检测到了PlA1同种抗原活性。这一发现表明，CIC中存在的至少一些细胞膜物质源自血小板。