Zheng Yi-Qun, Zhang Xiao-Bin, Zhou Jiang-Qiao, Cheng Fan, Rao Ting, Yao Yi
Department of Urology, Renmin Hospital, Wuhan University, Wuhan, China.
Urology. 2008 Nov;72(5):1179-84. doi: 10.1016/j.urology.2008.03.035. Epub 2008 Jun 2.
To investigate the effects of artery-ligating varicocelectomy (ALV) and artery-preserving varicocelectomy (APV) on the ipsilateral testes in experimental varicocele (EV) rats.
Fifty adolescent male Sprague-Dawley rats (6 weeks old, weighing 170 +/- 10 g) were randomly divided into 4 groups: EV without treatment group (EV group), EV with ALV group (EV+ALV group), EV with APV group (EV+APV group), and a control group. EV was induced by partial ligation of the left renal vein to an external diameter of 50% of its original at the position of medialis to both the adrenal and internal spermatic veins. ALV was performed by total ligation of the dilated left internal spermatic vein, along with the internal spermatic artery. APV was performed by ligation of the dilated left internal spermatic vein only. Johnsen's score, ultrastructure of seminiferous tubules, and intratesticular testosterone concentration (ITC) of the left testes were measured.
ITC and Johnsen's score in the control group were significantly higher than those in the EV group (P < .05) and markedly higher than those in the EV+ALV group (P < .01), and no statistical difference compared with those in the EV+APV group (P > .05). Ultrastructural abnormalities of seminiferous tubules were observed in the EV group, especially in the EV+ALV group.
APV was able to repair the varicocele-induced lesions of ipsilateral testes; whereas, the ALV caused further lesions.
研究动脉结扎性精索静脉曲张切除术（ALV）和保留动脉性精索静脉曲张切除术（APV）对实验性精索静脉曲张（EV）大鼠同侧睾丸的影响。
将50只青春期雄性Sprague-Dawley大鼠（6周龄，体重170±10 g）随机分为4组：未治疗的EV组（EV组）、ALV治疗的EV组（EV+ALV组）、APV治疗的EV组（EV+APV组）和对照组。通过在肾上腺和精索内静脉内侧将左肾静脉部分结扎至其原始外径的50%来诱导EV。ALV通过完全结扎扩张的左精索内静脉及其精索内动脉来进行。APV仅通过结扎扩张的左精索内静脉来进行。测量左睾丸的约翰森评分、生精小管超微结构和睾丸内睾酮浓度（ITC）。
对照组的ITC和约翰森评分显著高于EV组（P<.05），明显高于EV+ALV组（P<.01），与EV+APV组相比无统计学差异（P>.05）。在EV组，尤其是EV+ALV组中观察到生精小管超微结构异常。
APV能够修复精索静脉曲张引起的同侧睾丸损伤；而ALV会导致进一步损伤。
