Monda M, Messina G, Mangoni C, De Luca B
Department of Experimental Medicine, Section of Human Physiology, and Clinical Dietetic Service, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy.
Clin Nutr. 2008 Aug;27(4):657-9. doi: 10.1016/j.clnu.2008.04.005. Epub 2008 Jun 2.
BACKGROUND & AIMS: Few studies have investigated the age-related modification of resting energy expenditure (REE) and free fat mass (FFM) in severe obesity. This cross-sectional study analyzed REE and FFM in severely and moderately obese women and in lean subjects at different ages to find the possible differences between obese and lean subjects during aging.
Sedentary women (n=261) were divided into three groups with different body mass indexes (BMIs): 20.0-24.9; 30-34.9; >40 kg/m(2). Each group was then divided into five subgroups: 20-29; 30-39; 40-49; 50-59; 60-69 years. REE was measured with an indirect calorimetric device. The FFM was calculated by bioelectric impedance.
The REE in severely obese women was higher than the REE in lean or moderately obese women. The FFM of severely obese women was lower than that of moderately obese or lean women. The aging induced reductions of the REE and FFM in lean and moderately obese subjects, but not in women with severe obesity.
This experiment indicates that REE and FFM do not decline during aging in women with BMI>40, suggesting that the severe obesity induces different age-related adaptations of metabolism and body composition.
很少有研究调查严重肥胖患者静息能量消耗（REE）和去脂体重（FFM）随年龄的变化。这项横断面研究分析了不同年龄的重度和中度肥胖女性以及瘦体重受试者的REE和FFM，以发现肥胖和瘦体重受试者在衰老过程中可能存在的差异。
久坐不动的女性（n = 261）根据不同的体重指数（BMI）分为三组：20.0 - 24.9；30 - 34.9；>40 kg/m²。然后每组再分为五个亚组：20 - 29岁；30 - 39岁；40 - 49岁；50 - 59岁；60 - 69岁。使用间接热量测定仪测量REE。通过生物电阻抗计算FFM。
重度肥胖女性的REE高于瘦体重或中度肥胖女性。重度肥胖女性的FFM低于中度肥胖或瘦体重女性。衰老导致瘦体重和中度肥胖受试者的REE和FFM降低，但重度肥胖女性没有。
该实验表明，BMI>40的女性在衰老过程中REE和FFM不会下降，这表明严重肥胖会引起与年龄相关的不同代谢和身体成分适应性变化。
