Forooghian Farzin, Cukras Catherine, Meyerle Catherine B, Chew Emily Y, Wong Wai T
Division of Epidemiology and Clinical Research, National Eye Institute, National Institutesof Health, Bethesda, Maryland 20892, USA.
Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4290-6. doi: 10.1167/iovs.08-2113. Epub 2008 May 30.
To evaluate macular thickness and volume measurements and their intrasession repeatability in two optical coherence tomography (OCT) systems: the Stratus OCT, a time domain system, and the Cirrus HD-OCT, a spectral domain system (both by Carl Zeiss Meditec, Inc., Dublin, CA), in the context of diabetic macular edema (DME).
Thirty-three eyes of 33 diabetic patients with clinically significant macular edema (CSME) were scanned in a single session by a single operator on both OCT systems. Macular thickness measurements of nine standard macular subfields and total macular volume were obtained and analyzed. Bland-Altman plots were constructed to assess agreement in macular measurements. Intraclass correlation coefficients (ICCs), coefficients of repeatability (CR(W)), and coefficients of variation (CV(W)) were used to assess intrasession repeatability.
Macular thickness in nine retinal subfields and macular volume were significantly higher in the Cirrus HD-OCT system compared with the Stratus OCT system. Subfield thickness and total volume measurements, respectively, were 30 to 55 microm and 3.2 mm(3) greater for the Cirrus HD-OCT system compared with the Stratus OCT system. Both Stratus OCT and Cirrus HD-OCT systems demonstrated high intrasession repeatability, with overlapping ranges for CR(W), CV(W), and ICC. Repeatability measures (CR(W) and CV(W)) differed significantly between systems in only one of nine subfields (outer temporal subfield).
Absolute measures of macular thickness and volume in patients with DME differed significantly in magnitude between the Stratus OCT and Cirrus HD-OCT systems. However, both OCT systems demonstrated high intrasessional repeatability. Although the two systems may not be used interchangeably, they appear equally reliable in generating macular measurements for clinical practice and research.
在糖尿病性黄斑水肿（DME）的背景下，评估两种光学相干断层扫描（OCT）系统（时域系统Stratus OCT和光谱域系统Cirrus HD - OCT，均由加利福尼亚州都柏林的卡尔·蔡司医疗技术公司生产）的黄斑厚度和体积测量值及其扫描过程中的重复性。
由一名操作人员在单次扫描中使用这两种OCT系统对33例患有临床显著性黄斑水肿（CSME）的糖尿病患者的33只眼睛进行扫描。获取并分析九个标准黄斑子区域的黄斑厚度测量值和黄斑总体积。构建布兰德 - 奥特曼图以评估黄斑测量的一致性。使用组内相关系数（ICC）、重复性系数（CR(W)）和变异系数（CV(W)）来评估扫描过程中的重复性。
与Stratus OCT系统相比，Cirrus HD - OCT系统中九个视网膜子区域的黄斑厚度和黄斑体积显著更高。Cirrus HD - OCT系统的子区域厚度和总体积测量值分别比Stratus OCT系统大30至55微米和3.2立方毫米。Stratus OCT和Cirrus HD - OCT系统均显示出较高的扫描过程重复性，CR(W)、CV(W)和ICC的范围重叠。重复性测量值（CR(W)和CV(W)）仅在九个子区域之一（颞侧外子区域）的系统之间存在显著差异。
DME患者黄斑厚度和体积的绝对测量值在Stratus OCT和Cirrus HD - OCT系统之间在数值上存在显著差异。然而，两种OCT系统均显示出较高的扫描过程重复性。尽管这两种系统可能不能互换使用，但它们在为临床实践和研究生成黄斑测量值方面似乎同样可靠。
