State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China †Center for Advanced Eye Care, Carson City, NV, USA.
J Glaucoma. 2011 Feb;20(2):118-25. doi: 10.1097/IJG.0b013e3181d786f8.
To compare retinal nerve fiber layer (RNFL) and macular thickness measurements using time-domain optical coherence tomography (TD OCT) and 2 Fourier-domain OCTs (FD OCT).
Sixty eyes of 60 normal participants underwent eye examination followed by OCT evaluation with the time-domain Stratus OCT (Carl Zeiss Meditec, Inc. Dublin, CA) and 2 FD OCTs-the Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA) and the 3D OCT-1000 (Topcon Corporation, Tokyo, Japan). Each patient was scanned 3 times on each machine by the same physician examiner. RNFL and macular thickness measurements were compared across the 3 devices using repeated measures analysis of variance (ANOVA) and multiple comparison t tests with Bonferroni adjustments. The coefficients of variation (CV) and the intraclass correlation coefficients were calculated to assess reproducibility. Bland-Altman plots were constructed to assess the level of agreement between every 2 OCTs.
All 3 machines revealed similar patterns of regional differences in RNFL and macular thicknesses. Macular thickness was consistently greatest on the Cirrus and lowest on the Stratus device. However, RNFL measurements were less consistent. The overall average RNFL thickness was 4 μm greater on the Stratus than on the 3D OCT-1000, which was in turn 5 μm greater than on the Cirrus device. Bland-Altman plots showed poor-to-moderate agreement in terms of macular and RNFL thickness measurements between each 2 of the OCT devices. Both FD OCTs provided more reproducible readings on macular measurements than the Stratus, as evidenced by the lower CV and higher intraclass correlation coefficients. However, RNFL measurements on the 2 FD OCTs were not necessarily more reproducible than those from the Stratus OCT.
Thickness measurements are not interchangeable among different OCT devices because of the poor-to-moderate interdevice measurement agreement. FD instruments yield more reproducible macular but not RNFL thickness measurements.
比较时域光学相干断层扫描（TD OCT）和 2 种频域光学相干断层扫描（FD OCT）的视网膜神经纤维层（RNFL）和黄斑厚度测量值。
60 名正常参与者的 60 只眼接受眼科检查，然后使用时域 Stratus OCT（Carl Zeiss Meditec，Inc.，Dublin，CA）和 2 种 FD OCT（Cirrus HD-OCT，Carl Zeiss Meditec，Inc.，Dublin，CA）和 3D OCT-1000（Topcon Corporation，Tokyo，Japan）进行 OCT 评估。每位患者由同一位医师检查者在每台机器上扫描 3 次。使用重复测量方差分析（ANOVA）和具有 Bonferroni 调整的多重比较 t 检验比较 3 种设备之间的 RNFL 和黄斑厚度测量值。计算变异系数（CV）和组内相关系数以评估可重复性。绘制 Bland-Altman 图以评估每 2 种 OCT 之间的一致性水平。
所有 3 种机器均显示 RNFL 和黄斑厚度的区域差异具有相似的模式。黄斑厚度在 Cirrus 上始终最大，在 Stratus 设备上最小。然而，RNFL 测量值不太一致。Stratus 上的平均 RNFL 厚度比 3D OCT-1000 厚 4μm，而 Cirrus 上的平均 RNFL 厚度又比 Stratus 厚 5μm。Bland-Altman 图显示，在 OCT 设备的每 2 个之间，黄斑和 RNFL 厚度测量值的一致性较差到中等。与 Stratus 相比，2 种 FD OCT 均提供了更具可重复性的黄斑测量值，这体现在较低的 CV 和较高的组内相关系数上。然而，2 种 FD OCT 上的 RNFL 测量值不一定比 Stratus OCT 上的更具可重复性。
由于较差到中等的设备间测量一致性，不同 OCT 设备之间的厚度测量值不可互换。FD 仪器可产生更具可重复性的黄斑但不是 RNFL 厚度测量值。
