Weiner Ronald M, Taylor Larry E, Henrissat Bernard, Hauser Loren, Land Miriam, Coutinho Pedro M, Rancurel Corinne, Saunders Elizabeth H, Longmire Atkinson G, Zhang Haitao, Bayer Edward A, Gilbert Harry J, Larimer Frank, Zhulin Igor B, Ekborg Nathan A, Lamed Raphael, Richardson Paul M, Borovok Ilya, Hutcheson Steven
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
PLoS Genet. 2008 May 30;4(5):e1000087. doi: 10.1371/journal.pgen.1000087.
The marine bacterium Saccharophagus degradans strain 2-40 (Sde 2-40) is emerging as a vanguard of a recently discovered group of marine and estuarine bacteria that recycles complex polysaccharides. We report its complete genome sequence, analysis of which identifies an unusually large number of enzymes that degrade >10 complex polysaccharides. Not only is this an extraordinary range of catabolic capability, many of the enzymes exhibit unusual architecture including novel combinations of catalytic and substrate-binding modules. We hypothesize that many of these features are adaptations that facilitate depolymerization of complex polysaccharides in the marine environment. This is the first sequenced genome of a marine bacterium that can degrade plant cell walls, an important component of the carbon cycle that is not well-characterized in the marine environment.
海洋细菌食糖降解噬纤维菌2-40菌株（Sde 2-40）正成为最近发现的一组可循环利用复合多糖的海洋和河口细菌中的先锋。我们报道了其完整的基因组序列，分析发现其中有数量异常多的可降解10种以上复合多糖的酶。这不仅是一种非凡的分解代谢能力范围，许多酶还呈现出不同寻常的结构，包括催化模块和底物结合模块的新颖组合。我们推测，这些特征中的许多都是为促进在海洋环境中复合多糖解聚而产生的适应性变化。这是首个已测序的能够降解植物细胞壁的海洋细菌基因组，植物细胞壁是碳循环的一个重要组成部分，在海洋环境中尚未得到充分研究。
