Cieri Miriam, Carrara Silvia, Colombo Piergiuseppe
Department of Pathology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Department of Endoscopy, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Res Rep Urol. 2021 Jan 27;13:45-48. doi: 10.2147/RRU.S297465. eCollection 2021.
Tumor-to-tumor metastasis is the presence of a metastatic deposit within a second malignant primary, and its identification could be challenging, particularly when the latter malignancy has not yet been discovered. Renal cell carcinoma is one of the known recipients. Here we present a 52 years old woman who presented with a small nodule in the left kidney, which had a biphasic cell proliferation, chromophobe type, and signet-ring cell type for which we suggested to investigate the presence of a second tumor of gastrointestinal origin. We present this case for the rarity of its presentation, for the peculiar histological symbiosis we found between the two tumor entities, and for the challenging diagnosis due to the presence of an occult aggressive primary tumor.
肿瘤-to-肿瘤转移是指在第二种恶性原发性肿瘤内存在转移性沉积物，其识别可能具有挑战性，尤其是当后者的恶性肿瘤尚未被发现时。肾细胞癌是已知的转移受体之一。在此，我们报告一名52岁女性，她左肾出现一个小结节，具有双相细胞增殖，嫌色细胞型和印戒细胞型，为此我们建议调查是否存在胃肠道起源的第二种肿瘤。我们呈现此病例是因其表现罕见，因其在两个肿瘤实体之间发现的特殊组织学共生关系，以及由于存在隐匿性侵袭性原发性肿瘤而导致的具有挑战性的诊断。
