细胞穿透肽TP10对恶性疟原虫和布氏布氏锥虫均具有广谱活性。
Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.
作者信息
Arrighi Romanico B G, Ebikeme Charles, Jiang Yang, Ranford-Cartwright Lisa, Barrett Michael P, Langel Ulo, Faye Ingrid
机构信息
Department of Genetics, Stockholm University, Stockholm, Sweden.
出版信息
Antimicrob Agents Chemother. 2008 Sep;52(9):3414-7. doi: 10.1128/AAC.01450-07. Epub 2008 Jun 2.
Abstract
Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both blood and mosquito stages, and against blood-stage Trypanosoma brucei brucei.
摘要
疟疾和锥虫病是折磨着数百万人的疾病，迫切需要新的治疗方法。我们已经测试了两种特性明确的细胞穿透肽（CPPs）的抗寄生虫活性。一种名为TP10的CPP对恶性疟原虫的血液阶段和蚊虫阶段均具有广谱抗寄生虫活性，并且对布氏布氏锥虫的血液阶段也有活性。
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