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In vitro antiprotozoal activity and cytotoxicity of extracts and isolated constituents from Greenwayodendron suaveolens.光滑绿径树提取物及分离成分的体外抗寄生虫活性和细胞毒性
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本文引用的文献

1
Mechanism of the cell-penetrating peptide transportan 10 permeation of lipid bilayers.细胞穿透肽转运蛋白10穿透脂质双层的机制。
Biophys J. 2007 Apr 1;92(7):2434-44. doi: 10.1529/biophysj.106.100198. Epub 2007 Jan 11.
2
Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic update.抑制疟原虫血红素（β-血红素）形成的抗疟药物：机制更新
Life Sci. 2007 Feb 6;80(9):813-28. doi: 10.1016/j.lfs.2006.11.008. Epub 2006 Nov 10.
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Cell-penetrating peptides and antimicrobial peptides: how different are they?细胞穿透肽和抗菌肽：它们有何不同？
Biochem J. 2006 Oct 1;399(1):1-7. doi: 10.1042/BJ20061100.
4
The co-evolution of host cationic antimicrobial peptides and microbial resistance.宿主阳离子抗菌肽与微生物抗性的共同进化。
Nat Rev Microbiol. 2006 Jul;4(7):529-36. doi: 10.1038/nrmicro1441. Epub 2006 Jun 12.
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Evaluating the costs of mosquito resistance to malaria parasites.评估蚊子对疟原虫产生抗性的代价。
Evolution. 2005 Dec;59(12):2560-72.
6
Quantitatively determined uptake of cell-penetrating peptides in non-mammalian cells with an evaluation of degradation and antimicrobial effects.定量测定细胞穿透肽在非哺乳动物细胞中的摄取，并评估其降解和抗菌作用。
Peptides. 2006 Jul;27(7):1710-6. doi: 10.1016/j.peptides.2006.01.006. Epub 2006 Feb 24.
7
Activity of an engineered synthetic killer peptide on Leishmania major and Leishmania infantum promastigotes.一种工程合成杀伤肽对硕大利什曼原虫和婴儿利什曼原虫前鞭毛体的活性。
Exp Parasitol. 2006 Jul;113(3):186-92. doi: 10.1016/j.exppara.2006.01.002. Epub 2006 Feb 17.
8
Use of penetrating peptides interacting with PP1/PP2A proteins as a general approach for a drug phosphatase technology.使用与PP1/PP2A蛋白相互作用的穿膜肽作为药物磷酸酶技术的通用方法。
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Cell transduction pathways of transportans.转运蛋白的细胞转导途径。
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Free uptake of cell-penetrating peptides by fission yeast.裂殖酵母对细胞穿透肽的自由摄取。
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细胞穿透肽TP10对恶性疟原虫和布氏布氏锥虫均具有广谱活性。

Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.

作者信息

Arrighi Romanico B G, Ebikeme Charles, Jiang Yang, Ranford-Cartwright Lisa, Barrett Michael P, Langel Ulo, Faye Ingrid

机构信息

Department of Genetics, Stockholm University, Stockholm, Sweden.

出版信息

Antimicrob Agents Chemother. 2008 Sep;52(9):3414-7. doi: 10.1128/AAC.01450-07. Epub 2008 Jun 2.

DOI:10.1128/AAC.01450-07
PMID:18519720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2533502/
Abstract

Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both blood and mosquito stages, and against blood-stage Trypanosoma brucei brucei.

摘要

疟疾和锥虫病是折磨着数百万人的疾病，迫切需要新的治疗方法。我们已经测试了两种特性明确的细胞穿透肽（CPPs）的抗寄生虫活性。一种名为TP10的CPP对恶性疟原虫的血液阶段和蚊虫阶段均具有广谱抗寄生虫活性，并且对布氏布氏锥虫的血液阶段也有活性。