Croen K D
Department of Medicine, University of Cincinnati College of Medicine, Ohio 45267.
Annu Rev Med. 1991;42:61-7. doi: 10.1146/annurev.me.42.020191.000425.
The herpesviruses are ubiquitous pathogens that establish latent infections and can reactivate to produce recurrent disease. The fact that clinical recurrences are infrequent in most healthy individuals indicates that potent regulatory mechanisms must exist to ensure viral latency. Rapid progress is being made toward understanding the pathogenesis of latency and reactivation and is the subject of this review.
疱疹病毒是普遍存在的病原体，可建立潜伏感染并能重新激活以引发复发性疾病。大多数健康个体临床复发不常见这一事实表明，必然存在强大的调节机制来确保病毒潜伏。在理解潜伏和重新激活的发病机制方面正在取得快速进展，这也是本综述的主题。
