Gouin Jean-Philippe, Hantsoo Liisa, Kiecolt-Glaser Janice K
Department of Psychology, Ohio State University College of Medicine, Columbus, Ohio 43210, USA.
Neuroimmunomodulation. 2008;15(4-6):251-9. doi: 10.1159/000156468. Epub 2008 Nov 26.
Aging is associated with a natural dysregulation in immune functioning which may be amplified when it occurs in the context of chronic stress. Family dementia caregiving provides an excellent model to study the impact of chronic stress on immune functioning among older individuals. Empirical data suggest that the stress of caregiving dysregulates multiple components of innate and adaptive immunity. Elderly caregivers have poorer responses to vaccines, impaired control of latent viruses, exaggerated production of inflammatory mediators and accelerated cellular aging, compared to noncaregiving older adults. The chronic stress-induced immune dysregulation observed among older caregivers appears to be of sufficient magnitude to impact health. Furthermore, evidence suggests that chronic stress leads to premature aging of the immune system.
衰老与免疫功能的自然失调相关，当这种失调发生在慢性应激的背景下时，可能会被放大。家庭痴呆症护理为研究慢性应激对老年人免疫功能的影响提供了一个绝佳的模型。实证数据表明，护理压力会使先天免疫和适应性免疫的多个组成部分失调。与非护理老年人相比，老年护理人员对疫苗的反应较差，对潜伏病毒的控制受损，炎症介质产生过多，细胞衰老加速。在老年护理人员中观察到的慢性应激诱导的免疫失调似乎严重到足以影响健康。此外，有证据表明，慢性应激会导致免疫系统过早衰老。
