Patel Amit N, Park Eulsoon, Kuzman Michael, Benetti Federico, Silva Francisco J, Allickson Julie G
Center for Cardiac Cell Therapy-Heart Lung Esophageal Surgical Institute, University of Pittsburgh/UPMC/McGowan Institute of Regenerative Medicine, Pittsburgh, PA 15213, USA.
Cell Transplant. 2008;17(3):303-11. doi: 10.3727/096368908784153922.
The stromal stem cell fraction of many tissues and organs has demonstrated to exhibit stem cell properties such as the capability of self-renewal and multipotency, allowing for multilineage differentiation. In this study, we characterize a population of stromal stem cells derived from menstrual blood (MenSCs). We demonstrate that MenSCs are easily expandable to clinical relevance and express multipotent markers such as Oct-4, SSEA-4, and c-kit at the molecular and cellular level. Moreover, we demonstrate the multipotency of MenSCs by directionally differentiating MenSCs into chondrogenic, adipogenic, osteogenic, neurogenic, and cardiogenic cell lineages. These studies demonstrate the plasticity of MenSCs for potential research in regenerative medicine.
许多组织和器官的基质干细胞部分已被证明具有干细胞特性，如自我更新能力和多能性，能够进行多谱系分化。在本研究中，我们对源自月经血的基质干细胞群体（MenSCs）进行了表征。我们证明，MenSCs易于扩增至具有临床相关性，并在分子和细胞水平上表达多能性标志物，如Oct-4、SSEA-4和c-kit。此外，我们通过将MenSCs定向分化为软骨生成、脂肪生成、骨生成、神经生成和心脏生成细胞谱系，证明了MenSCs的多能性。这些研究证明了MenSCs在再生医学潜在研究中的可塑性。
