Barger Jamie L, Kayo Tsuyoshi, Vann James M, Arias Edward B, Wang Jelai, Hacker Timothy A, Wang Ying, Raederstorff Daniel, Morrow Jason D, Leeuwenburgh Christiaan, Allison David B, Saupe Kurt W, Cartee Gregory D, Weindruch Richard, Prolla Tomas A
LifeGen Technologies, LLC, Madison, Wisconsin, United States of America.
PLoS One. 2008 Jun 4;3(6):e2264. doi: 10.1371/journal.pone.0002264.
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.
在一些针对无脊椎动物的研究中，高剂量白藜芦醇已被证明可延长寿命，并能防止喂食高脂饮食的小鼠过早死亡。我们从中年（14个月）到老年（30个月）给小鼠喂食对照饮食、低剂量白藜芦醇（4.9毫克/千克/天）或热量限制（CR）饮食，并检测全基因组转录谱。我们报告了CR和白藜芦醇在心脏、骨骼肌和大脑中显著的转录重叠。两种饮食干预均抑制与心脏和骨骼肌衰老相关的基因表达谱，并预防与年龄相关的心脏功能障碍。饮食中的白藜芦醇在胰岛素介导的肌肉葡萄糖摄取方面也模拟了CR的作用。基因表达谱分析表明，CR和白藜芦醇可能通过染色质结构和转录的改变延缓衰老的某些方面。在人体中易于达到的剂量下，白藜芦醇符合模拟CR某些方面的膳食化合物的定义。
