Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, People's Republic of China.
Hebei Provincial Key Laboratory of Luobing, Shijiazhuang, People's Republic of China.
Redox Rep. 2024 Dec;29(1):2305036. doi: 10.1080/13510002.2024.2305036. Epub 2024 Feb 23.
Angelica keiskei is a medicinal and edible plant that has been reported to possess potent antioxidant properties in several in vitro models, but its effectiveness on naturally aging organisms is still lacking. This study explores the antioxidant and health-promoting effects of Angelica keiskei in naturally aging mice.
We treated 48-week-old mice with Angelica keiskei water extract (AKWE) 30 days, and measured indicators related to aging and antioxidants. In addition, we conducted network pharmacology analysis, component-target molecular docking, real-time PCR, and MTS assays to investigate relevant factors.
The results indicated that administration of AKWE to mice led to decrease blood glucose levels, improve muscle fiber structure, muscle strength, gait stability, and increase levels of glutathione and superoxide dismutase in serum. Additionally, it decreased pigmentation of the heart tissues. Angelica keiskei combats oxidative stress by regulating multiple redox signaling pathways, and its ingredients Coumarin and Flavonoids have the potential to bind to SIRT3 and SIRT5.
Our findings indicated the potential of Angelica keiskei as a safe and effective dietary supplement to combat aging and revealed the broad prospects of medicinal and edible plants for addressing aging and age-related chronic diseases.
当归是一种药食同源植物，已在多种体外模型中被报道具有强大的抗氧化特性，但它对自然衰老生物体的有效性仍有待研究。本研究旨在探讨当归水提物（AKWE）对自然衰老小鼠的抗氧化和促进健康作用。
我们用 AKWE 处理 48 周龄的小鼠 30 天，并测量与衰老和抗氧化相关的指标。此外，我们还进行了网络药理学分析、成分-靶标分子对接、实时 PCR 和 MTS 测定，以探讨相关因素。
结果表明，AKWE 的给药可降低小鼠的血糖水平，改善肌纤维结构、肌肉力量和步态稳定性，增加血清中谷胱甘肽和超氧化物歧化酶的水平，并减少心脏组织的色素沉着。当归通过调节多种氧化还原信号通路来对抗氧化应激，其成分香豆素和类黄酮有与 SIRT3 和 SIRT5 结合的潜力。
本研究结果表明，当归作为一种安全有效的膳食补充剂，具有对抗衰老的潜力，并揭示了药用和食用植物在解决衰老和与衰老相关的慢性疾病方面的广阔前景。
