病原体破坏与细胞内存活：脂质作为吞噬体命运决定因素的作用
Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants.
作者信息
Steinberg Benjamin E, Grinstein Sergio
机构信息
Program in Cell Biology, Hospital for Sick Children, Institute of Medical Science and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
出版信息
J Clin Invest. 2008 Jun;118(6):2002-11. doi: 10.1172/JCI35433.
Abstract
Phagocytosis is a key component of the innate immune response and of the clearance of apoptotic bodies. Phagosome formation and subsequent maturation require extensive cytoskeletal rearrangement and precisely choreographed vesicular fusion and fission events. The objectives of this review are to highlight the functional importance of lipids in the phagocytic process, to discuss how pathogenic microorganisms can in some cases manipulate host lipid metabolism to either co-opt or disrupt phagosome maturation and promote their own survival, and to describe how defective phagosomal lipid metabolism can result in disease.
摘要
吞噬作用是固有免疫反应和凋亡小体清除的关键组成部分。吞噬体的形成及随后的成熟需要广泛的细胞骨架重排以及精确编排的囊泡融合与裂变事件。本综述的目的是强调脂质在吞噬过程中的功能重要性，讨论致病微生物在某些情况下如何操纵宿主脂质代谢以要么利用要么破坏吞噬体成熟并促进自身存活，以及描述吞噬体脂质代谢缺陷如何导致疾病。
相似文献
1
Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants.病原体破坏与细胞内存活：脂质作为吞噬体命运决定因素的作用
J Clin Invest. 2008 Jun;118(6):2002-11. doi: 10.1172/JCI35433.
2
Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria.特定脂质激活吞噬体肌动蛋白组装和成熟，从而导致致病性分枝杆菌被杀死。
Nat Cell Biol. 2003 Sep;5(9):793-802. doi: 10.1038/ncb1036. Epub 2003 Aug 24.
3
Cellubrevin alterations and Mycobacterium tuberculosis phagosome maturation arrest.细胞ubrevin改变与结核分枝杆菌吞噬体成熟停滞
J Biol Chem. 2002 May 10;277(19):17320-6. doi: 10.1074/jbc.M200335200. Epub 2002 Feb 1.
4
A guide to measuring phagosomal dynamics.噬菌体内化动力学测量指南
FEBS J. 2021 Mar;288(5):1412-1433. doi: 10.1111/febs.15506. Epub 2020 Aug 16.
5
Phagosome maturation: aging gracefully.吞噬体成熟：优雅地老化。
Biochem J. 2002 Sep 15;366(Pt 3):689-704. doi: 10.1042/BJ20020691.
6
The myotubularin MTMR4 regulates phagosomal phosphatidylinositol 3-phosphate turnover and phagocytosis.肌管素 MTMR4 调控吞噬体磷酯酰肌醇 3-磷酸的循环和吞噬作用。
J Biol Chem. 2019 Nov 8;294(45):16684-16697. doi: 10.1074/jbc.RA119.009133. Epub 2019 Sep 22.
7
Role of microtubules and myosins in Fc gamma receptor-mediated phagocytosis.微管和肌球蛋白在Fcγ受体介导的吞噬作用中的作用。
Front Biosci. 2006 May 1;11:1479-90. doi: 10.2741/1897.
8
The role of lipids in host-pathogen interactions.脂质在宿主-病原体相互作用中的作用。
IUBMB Life. 2018 May;70(5):384-392. doi: 10.1002/iub.1737. Epub 2018 Mar 23.
9
Measurements of phagocytosis and phagosomal maturation.吞噬作用和吞噬体成熟的测量。
Curr Protoc Cell Biol. 2004 May;Chapter 15:Unit 15.7. doi: 10.1002/0471143030.cb1507s22.
10
Patterns, Receptors, and Signals: Regulation of Phagosome Maturation.模式、受体与信号：吞噬体成熟的调控
Trends Immunol. 2017 Jun;38(6):407-422. doi: 10.1016/j.it.2017.03.006. Epub 2017 Apr 14.
引用本文的文献
1
Acidic pH of early endosomes governs SARS-CoV-2 transport in host cells.早期内体的酸性pH值控制着严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在宿主细胞中的转运。
J Biol Chem. 2025 Feb;301(2):108144. doi: 10.1016/j.jbc.2024.108144. Epub 2024 Dec 26.
2
An antibiotic-free platform for eliminating persistent infection without disrupting gut microbiota.一个无抗生素平台，用于消除持续性感染而不破坏肠道微生物群。
Acta Pharm Sin B. 2024 Jul;14(7):3184-3204. doi: 10.1016/j.apsb.2024.03.014. Epub 2024 Mar 10.
3
Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models.tPA 信号对小鼠实验性肾病模型中巨噬细胞功能的调节。
Int J Mol Sci. 2023 Jul 4;24(13):11067. doi: 10.3390/ijms241311067.
4
: It's Complex.情况很复杂。
Microorganisms. 2022 Jul 19;10(7):1454. doi: 10.3390/microorganisms10071454.
5
Liposomes as Adjuvants and Vaccine Delivery Systems.脂质体作为佐剂和疫苗递送系统。
Biochem (Mosc) Suppl Ser A Membr Cell Biol. 2022;16(1):1-20. doi: 10.1134/S1990747822020076. Epub 2022 Feb 14.
6
Combined Host- and Pathogen-Directed Therapy for the Control of Mycobacterium abscessus Infection.联合宿主和病原体靶向治疗控制脓肿分枝杆菌感染。
Microbiol Spectr. 2022 Feb 23;10(1):e0254621. doi: 10.1128/spectrum.02546-21. Epub 2022 Jan 26.
7
Specific labelling of phagosome-derived vesicles in macrophages with a membrane dye delivered with microfabricated microparticles.利用微制造的微颗粒传递的膜染料对巨噬细胞中吞噬体衍生囊泡进行特异性标记。
Acta Biomater. 2022 Mar 15;141:344-353. doi: 10.1016/j.actbio.2022.01.028. Epub 2022 Jan 19.
8
The loss of enzymatic activity of the PHARC-associated lipase ABHD12 results in increased phagocytosis that causes neuroinflammation.PHARC 相关脂肪酶 ABHD12 的酶活性丧失导致吞噬作用增加，从而引起神经炎症。
Eur J Neurosci. 2021 Nov;54(10):7442-7457. doi: 10.1111/ejn.15516. Epub 2021 Nov 11.
9
Mapping Sphingolipid Metabolism Pathways during Phagosomal Maturation.在吞噬体成熟过程中对鞘脂代谢途径进行映射。
ACS Chem Biol. 2021 Dec 17;16(12):2757-2765. doi: 10.1021/acschembio.1c00393. Epub 2021 Oct 14.
10
Dectin-2 mediates phagocytosis of Lactobacillus paracasei KW3110 and IL-10 production by macrophages.Dectin-2 介导巨噬细胞吞噬副干酪乳杆菌 KW3110 和产生白细胞介素 10。
Sci Rep. 2021 Sep 6;11(1):17737. doi: 10.1038/s41598-021-97087-9.
本文引用的文献
1
Membrane recognition by phospholipid-binding domains.磷脂结合结构域对膜的识别
Nat Rev Mol Cell Biol. 2008 Feb;9(2):99-111. doi: 10.1038/nrm2328.
2
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.一种选择性PIKfyve抑制剂可阻断磷脂酰肌醇-3,5-二磷酸（PtdIns(3,5)P(2)）的生成，并破坏内膜运输和逆转录病毒出芽。
EMBO Rep. 2008 Feb;9(2):164-70. doi: 10.1038/sj.embor.7401155. Epub 2008 Jan 11.
3
Membrane phosphatidylserine regulates surface charge and protein localization.膜磷脂酰丝氨酸调节表面电荷和蛋白质定位。
Science. 2008 Jan 11;319(5860):210-3. doi: 10.1126/science.1152066.
4
Engulfment of apoptotic cells: signals for a good meal.凋亡细胞的吞噬：美餐的信号。
Nat Rev Immunol. 2007 Dec;7(12):964-74. doi: 10.1038/nri2214.
5
The dynamic phagosomal proteome and the contribution of the endoplasmic reticulum.动态吞噬体蛋白质组及内质网的作用
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18520-5. doi: 10.1073/pnas.0705801104. Epub 2007 Nov 15.
6
Cholesterol level regulates endosome motility via Rab proteins.胆固醇水平通过Rab蛋白调节内体运动。
Biophys J. 2008 Feb 15;94(4):1508-20. doi: 10.1529/biophysj.106.099366. Epub 2007 Nov 2.
7
Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor.膜磷脂酰丝氨酸受体stabilin-2介导的快速细胞尸体清除
Cell Death Differ. 2008 Jan;15(1):192-201. doi: 10.1038/sj.cdd.4402242. Epub 2007 Oct 26.
8
Identification of Tim4 as a phosphatidylserine receptor.鉴定Tim4为磷脂酰丝氨酸受体。
Nature. 2007 Nov 15;450(7168):435-9. doi: 10.1038/nature06307. Epub 2007 Oct 24.
9
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module.BAI1是ELMO/Dock180/Rac模块上游凋亡细胞的吞噬受体。
Nature. 2007 Nov 15;450(7168):430-4. doi: 10.1038/nature06329.
10
Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages.威斯科特-奥尔德里奇综合征蛋白是巨噬细胞中吞噬杯形成的关键调节因子。
J Biol Chem. 2007 Nov 23;282(47):34194-203. doi: 10.1074/jbc.M705999200. Epub 2007 Sep 21.
Zotero 插件