Steinberg Benjamin E, Grinstein Sergio
Program in Cell Biology, Hospital for Sick Children, Institute of Medical Science and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
J Clin Invest. 2008 Jun;118(6):2002-11. doi: 10.1172/JCI35433.
Phagocytosis is a key component of the innate immune response and of the clearance of apoptotic bodies. Phagosome formation and subsequent maturation require extensive cytoskeletal rearrangement and precisely choreographed vesicular fusion and fission events. The objectives of this review are to highlight the functional importance of lipids in the phagocytic process, to discuss how pathogenic microorganisms can in some cases manipulate host lipid metabolism to either co-opt or disrupt phagosome maturation and promote their own survival, and to describe how defective phagosomal lipid metabolism can result in disease.
吞噬作用是固有免疫反应和凋亡小体清除的关键组成部分。吞噬体的形成及随后的成熟需要广泛的细胞骨架重排以及精确编排的囊泡融合与裂变事件。本综述的目的是强调脂质在吞噬过程中的功能重要性，讨论致病微生物在某些情况下如何操纵宿主脂质代谢以要么利用要么破坏吞噬体成熟并促进自身存活，以及描述吞噬体脂质代谢缺陷如何导致疾病。
