Siklar Z, Berberoğlu M, Uysal Z, Citak F E, Bilir P, Ertem M, Engiz O, Oçal G
Department of Pediatric Endocrinology, School of Medicine, Ankara University, Ankara, Türkiye.
Exp Clin Endocrinol Diabetes. 2009 Feb;117(2):57-9. doi: 10.1055/s-2008-1076717. Epub 2008 Jun 3.
Increased cytokines secretion occurs in several different disorders. Hemophagocytic lymphohystiositosis (HLH) and metabolic syndrome (MS) are consist two of them. Hemophagocytic lymphohystiositosis results from uncontrolled macrophage activation and huge amounts of cytokine secretion. The metabolic syndrome is a multicomponent condition characterized by insulin resistance, dyslipidemia, abdominal obesity, hypertension, and increased level of proinflammatory cytokines. It was presented a 6.8 years old girl, diagnosed as HLH. Because she was morbid obese, endocrinological investigation had been done and metabolic syndrome, thyroid hormone dysfunction, and hypercortisolemia with disturbances of diurnal rhythm were detected. During follow-up of patient, metabolic syndrome components disappear gradually while haemophagocytosis was recovered. Endocrine system can be affect during HLH attack, and MS can be developed. Cytokines seems to act central role of pathological changes for both diseases.
细胞因子分泌增加见于多种不同疾病。噬血细胞性淋巴组织细胞增生症（HLH）和代谢综合征（MS）是其中的两种。噬血细胞性淋巴组织细胞增生症是由不受控制的巨噬细胞活化和大量细胞因子分泌所致。代谢综合征是一种多组分病症，其特征为胰岛素抵抗、血脂异常、腹部肥胖、高血压以及促炎细胞因子水平升高。本文报告了一名6.8岁被诊断为HLH的女孩。由于她病态肥胖，因此进行了内分泌学检查，结果发现存在代谢综合征、甲状腺激素功能障碍以及皮质醇增多症伴昼夜节律紊乱。在对该患者的随访过程中，随着噬血细胞现象的恢复，代谢综合征的各项组分逐渐消失。HLH发作期间内分泌系统可能会受到影响，进而可能发展为MS。细胞因子似乎在这两种疾病的病理变化中起核心作用。
