Gibbs Neil K, Tye Joanne, Norval Mary
Dermatological Sciences, University of Manchester Medical School, Stopford Building, Oxford Road, Manchester, UK M13 9PT.
Photochem Photobiol Sci. 2008 Jun;7(6):655-67. doi: 10.1039/b717398a. Epub 2008 Mar 13.
Urocanic acid (UCA), produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR). Originally thought to be a 'natural sunscreen', studies conducted a quarter of a century ago proposed that UCA may be a chromophore for the immunosuppression that follows exposure to UVR. With its intriguing photochemistry, its role in immunosuppression and skin cancer development, and skin barrier function, UCA continues to be the subject of intense research effort. This review summarises the photochemical, photobiological and photoimmunological findings regarding UCA, published since 1998.
尿刊酸（UCA）产生于哺乳动物皮肤的上层，是紫外线辐射（UVR）的主要吸收剂。最初被认为是一种“天然防晒霜”，四分之一个世纪前进行的研究提出，UCA可能是暴露于UVR后免疫抑制的发色团。因其有趣的光化学性质、在免疫抑制和皮肤癌发展中的作用以及皮肤屏障功能，UCA仍然是深入研究的对象。这篇综述总结了自1998年以来发表的关于UCA的光化学、光生物学和光免疫学研究结果。
