Culioli Gérald, Ortalo-Magné Annick, Valls Robert, Hellio Claire, Clare Anthony S, Piovetti Louis
Laboratoire des Matériaux à Finalités Spécifiques, Université du Sud Toulon-Var, Avenue de l'Université, BP 20132, F-83957 La Garde Cedex, France.
J Nat Prod. 2008 Jul;71(7):1121-6. doi: 10.1021/np070110k. Epub 2008 Jun 5.
Nine tetraprenyltoluquinol-related metabolites (1-9) have been isolated from the organic extract of the temperate brown alga Halidrys siliquosa that exhibits antifouling properties. The planar structure of compounds 1-9 was elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Antifouling and toxicity tests were conducted on these compounds: the most active (compounds 2, 6, and 9) inhibited both the growth of four strains of bacteria (MICs < 2.5 microg/mL) and settlement of cyprids of Balanus amphitrite (EC50 < 5 microg/mL), the latter at nontoxic concentrations (LC50 > 5 microg/mL).
从具有防污性能的温带褐藻鹿角菜的有机提取物中分离出了九种与四异戊烯基甲苯醌相关的代谢产物（1-9）。通过广泛的光谱分析，并将数据与相关代谢产物的数据进行比较，阐明了化合物1-9的平面结构。对这些化合物进行了防污和毒性测试：活性最高的（化合物2、6和9）抑制了四种细菌菌株的生长（最低抑菌浓度<2.5微克/毫升）以及藤壶幼虫的附着（半数有效浓度<5微克/毫升），后者在无毒浓度下（半数致死浓度>5微克/毫升）。
