Zorian E V, Larentsova L I, Aleksandrova G M, Novikova N V
Stomatologiia (Mosk). 1991 Mar-Apr(2):22-4.
Experimental and clinical study of the analgesic effects of mebicar and benzodiazepine series tranquilizers (sibazon and chlozepid) and their combinations with non-narcotic analgesics (amidopyrin, pyranal) or local anesthetic lidocaine has demonstrated a more marked effect of benzodiazepine derivatives on pain sensitivity thresholds as against mebicar. Tranquilizer combinations with other analgesics helped define the optimal premedication variants: benzodiazepine derivative augment analgesic activity whereas mebicar potentiates lidocaine effect.
美比卡与苯二氮䓬类镇静剂（西巴松和氯氮䓬）及其与非麻醉性镇痛药（氨基比林、吡拉明）或局部麻醉药利多卡因联合使用的镇痛效果的实验和临床研究表明，与美比卡相比，苯二氮䓬衍生物对疼痛敏感阈值的影响更为显著。镇静剂与其他镇痛药的联合使用有助于确定最佳的术前用药方案：苯二氮䓬衍生物增强镇痛活性，而美比卡则增强利多卡因的效果。
