Dmitriev A V, Bershadskiĭ B G
Farmakol Toksikol. 1985 May-Jun;48(3):33-6.
A method for preclinical evaluation of the optimal ratio (for analgesia) of an analgesic to a tranquilizer has been devised. It is based on the drug threshold dose decrease on the drug combined use. The multiple stepwise regression analysis of the data discovered the correlations between diazepam and promedol, optimal for pain perception decrease and nociceptive emotional responsiveness inhibition.
已设计出一种用于临床前评估镇痛药与镇静剂最佳比例（用于镇痛）的方法。它基于联合使用药物时药物阈剂量的降低。对数据进行的多元逐步回归分析发现了地西泮与异丙嗪之间的相关性，这对于降低疼痛感知和抑制伤害性情绪反应最为理想。
