Ding Jingzhong, Kritchevsky Stephen B, Harris Tamara B, Burke Gregory L, Detrano Robert C, Szklo Moyses, Jeffrey Carr J
Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Obesity (Silver Spring). 2008 Aug;16(8):1914-9. doi: 10.1038/oby.2008.278. Epub 2008 May 29.
Pericardial fat has a higher secretion of inflammatory cytokines than subcutaneous fat. Cytokines released from pericardial fat around coronary arteries may act locally on the adjacent cells.
We examined the relationship between pericardial fat and calcified coronary plaque.
Participants in the community-based Multi-Ethnic Study of Atherosclerosis (MESA) underwent a computed tomography (CT) scan for the assessment of calcified coronary plaque in 2000/2002. We measured the volume of pericardial fat using these scans in 159 whites and blacks without symptomatic coronary heart disease from Forsyth County, NC, aged 55-74 years.
Calcified coronary plaque was observed in 91 participants (57%). After adjusting for height, a 1 s.d. increment in pericardial fat was associated with an increased odds of calcified coronary plaque (odds ratio (95% confidence interval): 1.92 (1.27, 2.90)). With further adjustment of other cardiovascular factors, pericardial fat was still significantly associated with calcified coronary plaque. This relationship did not differ by gender and ethnicity. On the other hand, BMI and height-adjusted waist circumference were not associated with calcified coronary plaque.
Pericardial fat is independently associated with calcified coronary plaque.
心包脂肪比皮下脂肪分泌更多的炎性细胞因子。冠状动脉周围心包脂肪释放的细胞因子可能会对相邻细胞产生局部作用。
我们研究了心包脂肪与冠状动脉钙化斑块之间的关系。
社区动脉粥样硬化多民族研究（MESA）的参与者在2000/2002年接受了计算机断层扫描（CT）以评估冠状动脉钙化斑块。我们使用这些扫描测量了来自北卡罗来纳州福赛斯县的159名年龄在55 - 74岁、无冠心病症状的白人和黑人的心包脂肪体积。
91名参与者（57%）观察到冠状动脉钙化斑块。在调整身高后，心包脂肪每增加1个标准差与冠状动脉钙化斑块的发生几率增加相关（优势比（95%置信区间）：1.92（1.27，2.90））。在进一步调整其他心血管因素后，心包脂肪仍与冠状动脉钙化斑块显著相关。这种关系在性别和种族方面没有差异。另一方面，体重指数和身高调整后的腰围与冠状动脉钙化斑块无关。
心包脂肪与冠状动脉钙化斑块独立相关。
